{"id":"W2586974243","doi":"10.1242/jcs.191858","title":"The Rap1–cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B cell immune synapse","year":2017,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Microtubule organizing center; Cofilin; Immunological synapse; Cell biology; Biology; IQGAP1; Cell polarity; Actin remodeling; Actin; Actin cytoskeleton; Signal transduction; Cytoskeleton; T cell; Immune system; Centrosome; T-cell receptor; Scaffold protein; Cell; Cell cycle; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0009046227,0.00006763433,0.00006295019,0.00002463475,0.001637094,0.0002802737,0.0004978798,0.00004221661,0.00001375036],"category_scores_gemma":[0.0003397137,0.00003827675,0.00004422015,0.00006915319,0.0002427022,0.00003191061,0.0002308192,0.0001099627,0.000003178077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000215656,"about_ca_system_score_gemma":0.0001185738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009189279,"about_ca_topic_score_gemma":0.00001322446,"domain_scores_codex":[0.9993386,0.00003670047,0.0001914193,0.0001218207,0.0001786575,0.0001328513],"domain_scores_gemma":[0.9987916,0.00002731541,0.0005041408,0.00033524,0.0002875514,0.00005420228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002119907,0.00001706755,0.0002653525,0.0000019368,0.000003460774,9.489403e-7,0.00005811278,0.000007915806,0.99882,0.00007290075,0.0001602175,0.0005708795],"study_design_scores_gemma":[0.000171208,0.0001380558,0.001411342,0.000005628634,0.000007976409,0.00004457786,0.0001526576,0.0003089696,0.9826184,0.00007178765,0.01501725,0.00005216766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951565,0.0009904505,0.001249054,0.001032102,0.0004119576,0.0000740899,0.000002183753,0.000001226003,0.001082473],"genre_scores_gemma":[0.9947907,0.0007709,0.00006254978,0.0000448353,0.00009491768,6.728574e-7,0.00000237648,0.000006387078,0.004226706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01620163,"threshold_uncertainty_score":0.9996626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004454826473252746,"score_gpt":0.2256033656010201,"score_spread":0.2211485391277674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}