{"id":"W2586979917","doi":"10.1021/acs.jproteome.6b00915","title":"Expanding Proteome Coverage with CHarge Ordered Parallel Ion aNalysis (CHOPIN) Combined with Broad Specificity Proteolysis","year":2017,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bioinformatics Solutions (Canada)","funders":"Wellcome Trust","keywords":"Proteome; Trypsin; Orbitrap; Mass spectrometry; Proteolysis; Computational biology; Chemistry; Proteomics; Biology; Biochemistry; Chromatography; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007919503,0.0006892795,0.0004744638,0.0006028349,0.0003338926,0.0006322122,0.0002941862,0.0002586327,0.0008038082],"category_scores_gemma":[0.0005111424,0.0002976405,0.0003346032,0.0005665573,0.0003330529,0.0006236219,0.001113148,0.000744705,0.0003735569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002449721,"about_ca_system_score_gemma":0.000366273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003025549,"about_ca_topic_score_gemma":0.0009311297,"domain_scores_codex":[0.999511,0.00007458746,0.00003859526,0.000149213,0.0001564699,0.00007011169],"domain_scores_gemma":[0.9996649,0.00009162335,0.00006960306,0.00005633157,0.00007356473,0.00004404294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004644774,0.000008448894,0.0003571818,0.00003298073,0.000006793585,0.00002959685,0.00001834791,0.0000511783,0.9964147,0.00004515827,0.00005249443,0.002936811],"study_design_scores_gemma":[0.00001328865,0.000134302,0.00713596,0.000008476934,0.00002904077,0.0004785314,0.00002828562,0.00159297,0.9872277,0.0001720818,0.003168868,0.00001039746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8673692,0.002144234,0.1259516,0.000350182,0.00004491071,0.0001950676,0.00117044,0.0009036805,0.001870703],"genre_scores_gemma":[0.6978134,0.002348431,0.2931282,0.0004219627,0.00005396311,0.0002590693,0.003570911,0.0003072695,0.002096767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008038082,"threshold_uncertainty_score":0.004188299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05260962194516921,"score_gpt":0.3722427138326244,"score_spread":0.3196330918874552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}