{"id":"W2587028347","doi":"10.1038/nbt.3787","title":"Industrializing rare disease therapy discovery and development","year":2017,"lang":"en","type":"letter","venue":"Nature Biotechnology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Rare Disease Foundation","keywords":"Disease; Rare disease; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.00007868694,0.0003598851,0.0002743761,0.0001347849,0.0001505493,0.00008621825,0.0004913324,0.005766688,0.000005538974],"category_scores_gemma":[0.0001429337,0.0003252536,0.00007067654,0.00003516435,0.0001604332,0.000003785206,0.0003288614,0.002309579,0.000003343287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001749831,"about_ca_system_score_gemma":0.0001833311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003112596,"about_ca_topic_score_gemma":0.000003949368,"domain_scores_codex":[0.9986194,0.00002183905,0.0001797265,0.0006830429,0.0001361382,0.0003597974],"domain_scores_gemma":[0.9989243,0.000009703966,0.0001222818,0.000858621,0.00003151235,0.00005364647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009317755,0.00002098301,0.0003547116,0.0001172397,0.0002750966,0.0003464807,0.00001409612,0.000003017058,0.04376268,0.00004264997,0.9081563,0.0468136],"study_design_scores_gemma":[0.0003796722,0.00004921049,0.0003078572,0.00004506033,0.00001379767,0.00002870653,0.000004155188,9.96273e-7,0.09870259,0.00002340738,0.9000844,0.000360125],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.09355482,0.1565078,0.003759891,0.7394739,0.004308882,0.001390291,0.0003111302,0.0002901634,0.0004031019],"genre_scores_gemma":[0.4512884,0.02445135,0.006231735,0.464376,0.02521944,0.0003654574,0.007974952,0.000635073,0.01945756],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.3577336,"threshold_uncertainty_score":0.9999921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228337264999695,"score_gpt":0.2887777277612916,"score_spread":0.2764943551112946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}