{"id":"W2587035782","doi":"10.1093/ecco-jcc/jjx002.113","title":"DOP076 A phase 2B, multicenter, randomized, placebo-controlled dose-ranging trial of peficitinab, an oral JAK inhibitor, in patients with moderately to severely active ulcerative colitis","year":2017,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"","keywords":"Ulcerative colitis; Dose-ranging study; Placebo; Medicine; Internal medicine; Gastroenterology; Double blind; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001118667,0.001329284,0.002141039,0.0004030089,0.0003731522,0.0009226446,0.0006325006,0.001589278,0.00562343],"category_scores_gemma":[0.0008761658,0.0005267936,0.0008998836,0.000319897,0.0006825757,0.0006217663,0.0002866963,0.002451165,0.001169832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005263935,"about_ca_system_score_gemma":0.001026078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005119045,"about_ca_topic_score_gemma":0.001920832,"domain_scores_codex":[0.9995551,0.0002559453,0.00002461589,0.0000585679,0.00003723107,0.00006855396],"domain_scores_gemma":[0.9995371,0.0001052049,0.0001016696,0.00002368513,0.00004188035,0.0001906065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9187519,0.01375586,0.001641745,0.001520554,0.001130916,0.00011353,0.00008131682,0.0007682225,0.01667693,0.0001953381,0.003568841,0.04179482],"study_design_scores_gemma":[0.9340225,0.06120543,0.002265788,0.00003368492,0.000213227,0.0000835115,0.00001694408,0.0004298539,0.0007048716,0.0000716064,0.0009393101,0.00001327432],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832968,0.005286383,0.0005047711,0.0008857572,0.0004040168,0.003330371,0.002031659,0.0002280467,0.004032156],"genre_scores_gemma":[0.9802989,0.002973233,0.002050246,0.002292809,0.0003657705,0.003993915,0.003690427,0.00003743249,0.004297228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00562343,"threshold_uncertainty_score":0.01881224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008693483421233161,"score_gpt":0.2739495310627796,"score_spread":0.2652560476415465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}