{"id":"W2587120205","doi":"10.1017/s0033583517000026","title":"Unraveling amyloid formation paths of Parkinson's disease protein α-synuclein triggered by anionic vesicles","year":2017,"lang":"en","type":"article","venue":"Quarterly Reviews of Biophysics","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Fondation Chalmers; European Commission","keywords":"Vesicle; Chemistry; Biophysics; Amyloid (mycology); Circular dichroism; Alpha-synuclein; Vesicle fusion; Synaptic vesicle; Biochemistry; Parkinson's disease; Biology; Internal medicine; Membrane","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001592705,0.0001820107,0.0001820063,0.0001411999,0.0001398522,0.000335754,0.0001740849,0.0002617345,0.0002269694],"category_scores_gemma":[0.0001123715,0.0001353864,0.00011712,0.00009329492,0.000288097,0.0008012857,0.0002591918,0.0005212869,0.00008673257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001385957,"about_ca_system_score_gemma":0.0001294153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001493691,"about_ca_topic_score_gemma":0.0001499789,"domain_scores_codex":[0.999961,0.00001011485,0.000002344919,0.0000073032,0.00001199807,0.000007185991],"domain_scores_gemma":[0.9999621,0.00001207832,0.000009774785,0.000003085182,0.000008010776,0.000004997654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008405389,0.00002396532,0.0005669454,0.0001636811,0.000008594683,0.0002027389,0.0001069949,0.0006204916,0.9874828,0.002376067,0.00007202632,0.008291625],"study_design_scores_gemma":[0.00001495278,0.0002597675,0.003159179,0.00003260293,0.00003891356,0.0006615429,0.0002086648,0.01214159,0.9722137,0.004390972,0.006860355,0.0000176231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663206,0.02116979,0.01012217,0.0003916719,0.00003360427,0.00001804752,0.00003280504,0.00004465747,0.001866593],"genre_scores_gemma":[0.980383,0.01416872,0.004608036,0.00008031621,0.00002166998,0.00001004668,0.00002925424,0.00001028351,0.0006887026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000335754,"threshold_uncertainty_score":0.00100559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02508455042305961,"score_gpt":0.2773164243331243,"score_spread":0.2522318739100647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}