{"id":"W2587235534","doi":"10.1016/j.tranon.2017.01.007","title":"ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib","year":2017,"lang":"en","type":"article","venue":"Translational Oncology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation; University of Calgary","funders":"National Cancer Institute; Tel Aviv University; Alberta Innovates; Cancer Research Society","keywords":"Olaparib; Cancer research; PARP inhibitor; Colorectal cancer; Ataxia-telangiectasia; Medicine; Poly ADP ribose polymerase; DNA damage; Kinase; Cancer; Biology; Polymerase; Internal medicine; Gene; DNA; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007438657,0.0003283773,0.0003342955,0.0002766829,0.000198119,0.0003279771,0.0002155401,0.0002724321,0.001715947],"category_scores_gemma":[0.0001331106,0.000139682,0.0002765323,0.0003142261,0.0001145155,0.0001832002,0.0001559554,0.0005753238,0.0007621871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002772239,"about_ca_system_score_gemma":0.0001706276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001208361,"about_ca_topic_score_gemma":0.00132968,"domain_scores_codex":[0.999762,0.00002662707,0.00004003536,0.0000404581,0.00008870095,0.00004222077],"domain_scores_gemma":[0.9998547,0.00002213012,0.00004743073,0.00002796938,0.00001904147,0.00002871622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001275284,0.00005118024,0.0003020318,0.00003826623,0.000007919465,0.0001299264,0.00001212264,0.00008673847,0.9967099,0.00005220501,0.0002040409,0.002278154],"study_design_scores_gemma":[0.00002613215,0.0004720383,0.00930601,0.000006520663,0.00001396334,0.0008306642,0.00002777241,0.0008128927,0.9835075,0.00003919722,0.004949873,0.000007495065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982183,0.005036544,0.003143316,0.0004043601,0.0001613123,0.00006546923,0.003187077,0.0004303816,0.005388492],"genre_scores_gemma":[0.9868651,0.001840467,0.002663983,0.0001625074,0.00001733736,0.00005601513,0.004015757,0.00002561052,0.004353202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001715947,"threshold_uncertainty_score":0.005740464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01761906666376762,"score_gpt":0.2982408205262282,"score_spread":0.2806217538624606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}