{"id":"W2587235534","doi":"10.1016/j.tranon.2017.01.007","title":"ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib","year":2017,"lang":"en","type":"article","venue":"Translational Oncology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation; University of Calgary","funders":"National Cancer Institute; Tel Aviv University; Alberta Innovates; Cancer Research Society","keywords":"Olaparib; Cancer research; PARP inhibitor; Colorectal cancer; Ataxia-telangiectasia; Medicine; Poly ADP ribose polymerase; DNA damage; Kinase; Cancer; Biology; Polymerase; Internal medicine; Gene; DNA; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000220041,0.0001386251,0.0001624572,0.00002093909,0.0003498223,0.00003000027,0.0002612046,0.0001846916,0.00005171578],"category_scores_gemma":[0.00004038783,0.0001100514,0.00009866274,0.00003099923,0.0001231583,0.000004545733,0.00007689915,0.000109775,0.000074734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000421744,"about_ca_system_score_gemma":0.0002256031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005280632,"about_ca_topic_score_gemma":0.001682585,"domain_scores_codex":[0.9989949,0.00008673235,0.0001699973,0.0003402095,0.0001653136,0.0002428502],"domain_scores_gemma":[0.9993067,0.00003762112,0.0001356455,0.0002959982,0.0001348259,0.00008918078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000358278,0.00009718453,0.0008984898,0.000004673047,0.00007112572,0.00001423749,0.0003212875,0.001387723,0.9877687,0.0005937069,0.004077247,0.004407355],"study_design_scores_gemma":[0.0007702713,0.0004498207,0.02526281,0.00001083417,0.00003826807,0.00001549315,0.00009625887,0.000309316,0.8003792,0.0000865894,0.172379,0.0002021864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985454,0.0001025529,0.001401898,0.00839159,0.0009883018,0.0004410945,0.0001980581,0.00001443937,0.003008098],"genre_scores_gemma":[0.9967412,0.00001928516,0.0009056455,0.001065085,0.0006144401,0.0000925283,0.00004535409,0.0000179831,0.0004984133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1873895,"threshold_uncertainty_score":0.4487764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01761906666376762,"score_gpt":0.2982408205262282,"score_spread":0.2806217538624606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}