{"id":"W2587262549","doi":"10.1161/atvb.32.suppl_1.a200","title":"Abstract 200: Inhibition of Four-and-a-Half Lim Domain Protein 2 Increases Survival and Migratory Capacity of Human Early Outgrowth Endothelial Progenitor Cells Through Upregulation of Sphingosine Kinase-1: Implications for Endothelial Regeneration","year":2012,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Cortactin; Downregulation and upregulation; Sphingosine; Cell biology; Progenitor cell; Sphingosine-1-phosphate; Gene knockdown; Chemistry; Endothelial stem cell; Endothelial progenitor cell; Angiogenesis; Cell migration; Apoptosis; Biology; Stem cell; Cancer research; Receptor; Cell; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001138478,0.0004810934,0.0002647886,0.0001437412,0.0001385735,0.0002142744,0.0002190505,0.0002870338,0.004111923],"category_scores_gemma":[0.00008743469,0.0001116997,0.000298917,0.0001161021,0.0001691044,0.0001448178,0.0001661045,0.0005701178,0.0008487304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002440941,"about_ca_system_score_gemma":0.0002818454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004050904,"about_ca_topic_score_gemma":0.0003701723,"domain_scores_codex":[0.9999068,0.00001248633,0.0000123376,0.00001878217,0.00002726635,0.00002226081],"domain_scores_gemma":[0.9999546,0.000008389451,0.00001004793,0.000004245643,0.000005007034,0.00001780741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005214441,0.00008554936,0.0001092231,0.0001023713,0.000009861307,0.00007704552,0.000008364339,0.0000457191,0.9968388,0.0000648607,0.0002427768,0.001893884],"study_design_scores_gemma":[0.0001404163,0.0006457728,0.003509386,0.000009200327,0.00002852963,0.0002769237,0.00001259297,0.0005416979,0.9905823,0.00003341616,0.004216133,0.000003565138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884577,0.003243764,0.002582259,0.0004069449,0.0001382028,0.00007800186,0.001840104,0.0001901889,0.00306277],"genre_scores_gemma":[0.9787193,0.002165904,0.003219634,0.0002549512,0.0000648276,0.0002434405,0.003571978,0.00003611012,0.01172388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004111923,"threshold_uncertainty_score":0.01375574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0463369728858682,"score_gpt":0.277655827844705,"score_spread":0.2313188549588369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}