{"id":"W2587290015","doi":"10.1074/jbc.m116.730614","title":"Site-specific O-Glycosylation by Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) Co-regulates β1-Adrenergic Receptor N-terminal Cleavage","year":2017,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Novo Nordisk; Magnus Ehrnroothin Säätiö; Sundhed og Sygdom, Det Frie Forskningsråd; Danmarks Grundforskningsfond; National Research Foundation; Medical Research Center Oulu","keywords":"Glycosylation; Proteolysis; Receptor; G protein-coupled receptor; Agonist; Biochemistry; Biology; Gene isoform; Cell biology; HEK 293 cells; N-linked glycosylation; Chemistry; Enzyme; Glycoprotein; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005030962,0.0003778583,0.0004793507,0.00002869774,0.0003746558,0.0001858133,0.0006693649,0.0005777827,0.001049074],"category_scores_gemma":[0.0001484177,0.0002951197,0.0004292395,0.00004000949,0.0002574727,0.00002603021,0.00006431184,0.0004150716,0.00001775759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000434853,"about_ca_system_score_gemma":0.00006822589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008610548,"about_ca_topic_score_gemma":0.000001168658,"domain_scores_codex":[0.9979846,0.00008390519,0.0007247268,0.000461579,0.0003114571,0.0004337194],"domain_scores_gemma":[0.9984379,0.00003939907,0.0005142625,0.0005061702,0.0001693644,0.0003328768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006626763,0.0001670745,0.001869064,0.00002654812,0.00006084505,0.00004263442,0.00002387643,0.00001351723,0.9914539,0.000006454145,0.003727885,0.001945488],"study_design_scores_gemma":[0.001279474,0.0005861557,0.0006882278,0.00005830229,0.00002545698,0.000190792,0.0000587818,0.00001056799,0.9738018,0.00004102753,0.02288291,0.0003765238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957733,0.001481155,0.001287198,0.0001682669,0.0002385327,0.0001017725,0.0001452293,0.00001457712,0.0007899294],"genre_scores_gemma":[0.9953447,0.001907175,0.0006903016,0.00009853174,0.001146095,0.000005117012,0.000351033,0.00003357417,0.000423486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01915502,"threshold_uncertainty_score":0.9999501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01673270558933621,"score_gpt":0.2555863522879407,"score_spread":0.2388536466986045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}