{"id":"W2587290015","doi":"10.1074/jbc.m116.730614","title":"Site-specific O-Glycosylation by Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) Co-regulates β1-Adrenergic Receptor N-terminal Cleavage","year":2017,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Novo Nordisk; Magnus Ehrnroothin Säätiö; Sundhed og Sygdom, Det Frie Forskningsråd; Danmarks Grundforskningsfond; National Research Foundation; Medical Research Center Oulu","keywords":"Glycosylation; Proteolysis; Receptor; G protein-coupled receptor; Agonist; Biochemistry; Biology; Gene isoform; Cell biology; HEK 293 cells; N-linked glycosylation; Chemistry; Enzyme; Glycoprotein; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120735,0.0004514935,0.0002285586,0.0001067698,0.0001010053,0.000359901,0.000131692,0.0002007458,0.0006423469],"category_scores_gemma":[0.00009521314,0.0001292382,0.0004171175,0.000131958,0.0001570126,0.0001506118,0.0001930797,0.0004629955,0.0003095687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002055908,"about_ca_system_score_gemma":0.0001244475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003278286,"about_ca_topic_score_gemma":0.0003836477,"domain_scores_codex":[0.9998543,0.00002657528,0.00001392436,0.00003908583,0.00002686993,0.00003920563],"domain_scores_gemma":[0.9999245,0.000006707712,0.00003551826,0.000006616244,0.000007986393,0.00001856357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001175438,0.00001511377,0.0002068236,0.0000199526,0.000005494982,0.00004762911,0.000007767606,0.0000355464,0.9989936,0.00004216592,0.00003509741,0.0004732124],"study_design_scores_gemma":[0.00002649113,0.0002144344,0.007247962,0.000006898008,0.00002079812,0.0004409335,0.00003832604,0.00164234,0.9874993,0.00003807246,0.002819154,0.000005271684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917257,0.002023862,0.004814386,0.0001015134,0.00004565739,0.00003337768,0.0002465726,0.00005855814,0.0009504471],"genre_scores_gemma":[0.9931905,0.001452175,0.00251196,0.00009220949,0.00001615256,0.00003611658,0.0006017995,0.00002272536,0.002076407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006423469,"threshold_uncertainty_score":0.002148926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01673270558933621,"score_gpt":0.2555863522879407,"score_spread":0.2388536466986045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}