{"id":"W2587295203","doi":"10.1182/blood.v128.22.234.234","title":"Updated Efficacy and Safety from the Phase 3 Resonate-2 Study: Ibrutinib As First-Line Treatment Option in Patients 65 Years and Older with Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre","funders":"","keywords":"Medicine; Ibrutinib; Chronic lymphocytic leukemia; Chlorambucil; Internal medicine; Bendamustine; Oncology; Leukemia; Chemotherapy; Gastroenterology; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003879181,0.0005140948,0.000736283,0.000183589,0.0001918602,0.00007760857,0.0002454578,0.0002221661,0.0001085534],"category_scores_gemma":[0.0002093475,0.0002905105,0.00006814932,0.0004314711,0.0003660641,0.0001511325,0.0002301007,0.0001934781,0.00007966292],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.1009237,"about_ca_system_score_gemma":0.01803616,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01453668,"about_ca_topic_score_gemma":0.002261069,"domain_scores_codex":[0.9966308,0.0002152539,0.0006427104,0.001028135,0.0007025533,0.0007805561],"domain_scores_gemma":[0.9976847,0.0006694297,0.0001763837,0.000979585,0.0001241756,0.0003657128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1014699,0.01959455,0.2358441,0.0007771281,0.008102993,0.00919222,0.02027426,0.001875088,0.004068898,0.0001525236,0.001442446,0.5972059],"study_design_scores_gemma":[0.727658,0.009751108,0.2507593,0.001095185,0.001011002,0.0002268593,0.0002037282,0.004791065,0.001858674,0.00003021896,0.002075782,0.000539098],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946445,0.001650427,0.00001142147,0.000225094,0.00006120563,0.003142272,0.00008122615,0.0001133293,0.0000705607],"genre_scores_gemma":[0.9969395,0.001675063,0.00009010449,0.0001559792,0.0002026875,0.0001596368,0.0001606713,0.00009495975,0.0005213643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6261881,"threshold_uncertainty_score":0.9999547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01517803581255455,"score_gpt":0.2728574033801529,"score_spread":0.2576793675675983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}