{"id":"W2587295203","doi":"10.1182/blood.v128.22.234.234","title":"Updated Efficacy and Safety from the Phase 3 Resonate-2 Study: Ibrutinib As First-Line Treatment Option in Patients 65 Years and Older with Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre","funders":"","keywords":"Medicine; Ibrutinib; Chronic lymphocytic leukemia; Chlorambucil; Internal medicine; Bendamustine; Oncology; Leukemia; Chemotherapy; Gastroenterology; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004179308,0.0008466347,0.002016647,0.0005751408,0.0004007331,0.001339252,0.0008207056,0.0009975448,0.005312813],"category_scores_gemma":[0.003657747,0.0004111708,0.002941938,0.0006994181,0.0003307696,0.0009630045,0.0006572395,0.002728529,0.0008846228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000825761,"about_ca_system_score_gemma":0.0009206044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001166683,"about_ca_topic_score_gemma":0.00416262,"domain_scores_codex":[0.9986488,0.0007489386,0.0001026935,0.0001584836,0.0002274237,0.0001136066],"domain_scores_gemma":[0.9971611,0.0007159511,0.0009794034,0.0002214489,0.0003852189,0.0005367819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7122808,0.005623491,0.04169383,0.004055607,0.01325737,0.0002947981,0.0003431355,0.002262748,0.01119918,0.000529551,0.03817946,0.17028],"study_design_scores_gemma":[0.571109,0.1217161,0.2326469,0.001356678,0.02115359,0.001596502,0.0002121789,0.00247564,0.003684518,0.001126119,0.04270266,0.0002201054],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8955847,0.04231523,0.001386189,0.002293329,0.0004103733,0.002660905,0.04158034,0.0002606828,0.01350828],"genre_scores_gemma":[0.9321618,0.009245521,0.001973171,0.004390065,0.0005504783,0.00230873,0.04623953,0.00007815385,0.003052488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005312813,"threshold_uncertainty_score":0.02210259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01517803581255455,"score_gpt":0.2728574033801529,"score_spread":0.2576793675675983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}