{"id":"W2587304416","doi":"10.1038/srep41871","title":"Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Eye Institute; Canadian Institutes of Health Research; National Institutes of Health; Marfan Foundation","keywords":"Fibrillin; Microfibril; Cell biology; Ectopia lentis; Extracellular matrix; ADAMTS; Metalloproteinase; Biology; Matrix metalloproteinase; Secretion; Chemistry; Marfan syndrome; Genetics; Biochemistry; Medicine; Internal medicine; Thrombospondin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001050388,0.0002607755,0.0001367866,0.0003964163,0.0001701198,0.0003161574,0.000119306,0.0002167279,0.0005887614],"category_scores_gemma":[0.0001464744,0.0001238803,0.0002744034,0.000118886,0.0002010582,0.0002349359,0.00014875,0.0002444816,0.0002726855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000245196,"about_ca_system_score_gemma":0.0001430357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002780119,"about_ca_topic_score_gemma":0.0002463179,"domain_scores_codex":[0.9999282,0.00001234534,0.00000755196,0.00001855246,0.00001682465,0.0000165333],"domain_scores_gemma":[0.9998236,0.00002790619,0.00006665686,0.00001561083,0.00001852077,0.00004776657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001341357,0.00001728005,0.002943241,0.00003032109,0.000005199015,0.0006333839,0.00003458032,0.00004644862,0.994621,0.0001820463,0.00002961831,0.001322626],"study_design_scores_gemma":[0.00001250105,0.0002428018,0.02959108,0.00000821044,0.00003430315,0.005128887,0.00007695498,0.0008723606,0.9609701,0.0002628207,0.00278936,0.00001067213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967055,0.001430574,0.001183348,0.00002967625,0.00001252191,0.000006922769,0.0001288419,0.00002405443,0.0004785833],"genre_scores_gemma":[0.9972578,0.0006163871,0.001024833,0.00001723303,0.000008590443,0.00001063449,0.000279771,0.00002034936,0.0007645666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005887614,"threshold_uncertainty_score":0.001969635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01409739016758865,"score_gpt":0.3230238257022895,"score_spread":0.3089264355347009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}