{"id":"W2587304416","doi":"10.1038/srep41871","title":"Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Eye Institute; Canadian Institutes of Health Research; National Institutes of Health; Marfan Foundation","keywords":"Fibrillin; Microfibril; Cell biology; Ectopia lentis; Extracellular matrix; ADAMTS; Metalloproteinase; Biology; Matrix metalloproteinase; Secretion; Chemistry; Marfan syndrome; Genetics; Biochemistry; Medicine; Internal medicine; Thrombospondin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006910001,0.0001665156,0.0002119239,0.0001619911,0.0002134406,0.0001765113,0.0002061908,0.00007510149,0.00003594846],"category_scores_gemma":[0.001573522,0.0001481805,0.0001060182,0.0001398854,0.0004285169,0.00001171846,0.0002427286,0.0000661345,0.000003515392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002000262,"about_ca_system_score_gemma":0.0004457292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000359867,"about_ca_topic_score_gemma":0.0001199712,"domain_scores_codex":[0.9981539,0.0001004225,0.0003190549,0.0007768671,0.0003289738,0.0003207433],"domain_scores_gemma":[0.9980126,0.00001144135,0.0002664018,0.001219995,0.0001848152,0.0003047624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002546819,0.0001144433,0.1350658,0.00003931135,0.00005375058,0.0003535646,0.00004967372,0.0001757577,0.8616572,0.000002131117,0.0002377766,0.001995956],"study_design_scores_gemma":[0.0005320745,0.0001874609,0.7513224,0.00004062671,0.00001904593,0.00001406106,0.00004513944,0.0006872788,0.2460677,0.0003608511,0.0005149877,0.0002083397],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997916,0.000955247,0.00003009012,0.00007856084,0.0002534547,0.000484424,0.00002082941,0.000006528504,0.0002548509],"genre_scores_gemma":[0.999213,0.00001682509,0.00005251708,0.00001002815,0.00002534691,0.00002622175,0.00009086685,0.00001954831,0.0005456549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6162567,"threshold_uncertainty_score":0.6042626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01409739016758865,"score_gpt":0.3230238257022895,"score_spread":0.3089264355347009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}