{"id":"W2587354049","doi":"10.1016/j.celrep.2017.01.029","title":"The Mitochondrial Rhomboid Protease PARL Is Regulated by PDK2 to Integrate Mitochondrial Quality Control and Metabolism","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael J. Fox Foundation for Parkinson's Research","keywords":"Mitophagy; PINK1; Parkin; Cell biology; Biology; Mitochondrion; Regulator; Mitochondrial DNA; mitochondrial fusion; Biochemistry; Gene; Autophagy; Parkinson's disease; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004427035,0.0003126028,0.0003760351,0.00002970981,0.0008484747,0.0002910648,0.0003181204,0.0003490881,0.00005312874],"category_scores_gemma":[0.001335632,0.0002281941,0.000176826,0.00004165701,0.0002736269,0.00001242289,0.0001920964,0.0002153471,0.00002354303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001372936,"about_ca_system_score_gemma":0.000132871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000214292,"about_ca_topic_score_gemma":0.0001069677,"domain_scores_codex":[0.9975713,0.0002634488,0.0006316284,0.0008652254,0.0002390645,0.0004292894],"domain_scores_gemma":[0.9971113,0.00004112053,0.0006064596,0.001686419,0.0002226422,0.0003320626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007239184,0.00004442527,0.0005010262,0.000007998964,0.00004891397,0.0000364951,0.00006768815,0.000001250388,0.8946199,0.00002643474,0.1021205,0.001801384],"study_design_scores_gemma":[0.001390274,0.0001405902,0.00123963,0.000007579593,0.00005201076,0.00007801018,0.00002983624,0.000006009943,0.3737853,0.0002631177,0.6227275,0.0002801639],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9718234,0.00193813,0.005638858,0.002930459,0.01151718,0.002377748,0.0001306787,0.00005141336,0.003592106],"genre_scores_gemma":[0.9498087,0.0002748139,0.001545153,0.001974068,0.003242296,0.0004085438,0.000173697,0.00007728364,0.04249542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5208347,"threshold_uncertainty_score":0.9305484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046547829711286,"score_gpt":0.2625448110717942,"score_spread":0.2520793327746814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}