{"id":"W2587380941","doi":"10.1073/pnas.1615413114","title":"Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation","year":2017,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Astrocyte; Microglia; Biology; Proinflammatory cytokine; Inflammation; Pathogenesis; Neurodegeneration; Multiple sclerosis; Neuroscience; Immunology; Medicine; Central nervous system; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421121,0.0003281779,0.0002812012,0.0001981368,0.0001219473,0.0002189584,0.0001714613,0.0002293606,0.0007533625],"category_scores_gemma":[0.00009632554,0.00008030995,0.000190381,0.000113053,0.0002147425,0.0001199442,0.0001307248,0.0005380753,0.0002226419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001587777,"about_ca_system_score_gemma":0.0003195672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005633875,"about_ca_topic_score_gemma":0.001729194,"domain_scores_codex":[0.9999261,0.00001522693,0.000005220877,0.00001134725,0.00001525641,0.00002678474],"domain_scores_gemma":[0.9999599,0.000004144065,0.0000139591,0.000003682772,0.00000514386,0.00001311799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006702662,0.0001330429,0.0001323447,0.00004233963,0.00001017952,0.00004850019,0.00001525765,0.00009594241,0.9946813,0.0001051557,0.00009316722,0.003972345],"study_design_scores_gemma":[0.0003577192,0.003297062,0.007546824,0.00001665167,0.00007214149,0.0003748835,0.00006518628,0.001617148,0.9818601,0.0001958288,0.004587998,0.000008576852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99652,0.001470313,0.0008079166,0.0001254727,0.00003101481,0.00001442292,0.0001131626,0.00007365936,0.000843919],"genre_scores_gemma":[0.9962826,0.001322282,0.0007732001,0.00005973469,0.00001945991,0.00002416878,0.00018174,0.0000122121,0.001324527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007533625,"threshold_uncertainty_score":0.002520263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02154196013101787,"score_gpt":0.2885963540490563,"score_spread":0.2670543939180384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}