{"id":"W2587382717","doi":"10.1021/acs.jmedchem.6b01392","title":"Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"Università degli Studi del Piemonte Orientale; Associazione Italiana per la Ricerca sul Cancro; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Nicotinamide phosphoribosyltransferase; Chemistry; NAD+ kinase; Nicotinamide; Enzyme; In vitro; Pharmacology; Colitis; Biochemistry; Cytotoxicity; Colorectal cancer; Triazole; Cancer research; Cancer; Immunology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005864093,0.0001655297,0.0002974837,0.00003145761,0.0001244921,0.00003592312,0.0003007525,0.0001654444,0.000006384497],"category_scores_gemma":[0.0004300493,0.0001255152,0.0001083402,0.0000389972,0.0004896661,0.00001532088,0.00005287153,0.0003122551,1.357945e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000188647,"about_ca_system_score_gemma":0.0003234805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001080837,"about_ca_topic_score_gemma":0.000002427356,"domain_scores_codex":[0.9987219,0.00002877755,0.0004000929,0.0002234077,0.0004432181,0.0001826297],"domain_scores_gemma":[0.9984244,0.00002568823,0.0006317899,0.0003516147,0.0003811624,0.0001853758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00201658,0.0002005276,0.003752433,0.000200743,0.00009892574,0.00002675883,0.00002313744,0.000007888858,0.9922981,0.000002372307,0.00007429955,0.001298263],"study_design_scores_gemma":[0.003953236,0.0003821702,0.003547964,0.0001854232,0.0000660919,0.0001453456,0.00006277866,0.00009581982,0.9912388,0.000004631368,0.0001886146,0.0001290657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955125,0.0004648522,0.003246734,0.0004669937,0.00005484531,0.0001157178,0.0000169076,0.000002230641,0.0001192164],"genre_scores_gemma":[0.9992642,0.0001566367,0.0001900894,0.00002594288,0.0002607093,0.000003714887,0.000009244919,0.00001527847,0.00007415859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003751723,"threshold_uncertainty_score":0.5118361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0106856052220468,"score_gpt":0.2760195402899873,"score_spread":0.2653339350679405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}