{"id":"W2587382717","doi":"10.1021/acs.jmedchem.6b01392","title":"Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"Università degli Studi del Piemonte Orientale; Associazione Italiana per la Ricerca sul Cancro; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Nicotinamide phosphoribosyltransferase; Chemistry; NAD+ kinase; Nicotinamide; Enzyme; In vitro; Pharmacology; Colitis; Biochemistry; Cytotoxicity; Colorectal cancer; Triazole; Cancer research; Cancer; Immunology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001346443,0.0003940389,0.0004559774,0.000434276,0.000151876,0.0003275752,0.0004126409,0.0002817905,0.001500711],"category_scores_gemma":[0.0001099838,0.0001273073,0.0002965299,0.0002789938,0.0001753271,0.0002256019,0.0002061878,0.0005077626,0.0005649549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003087461,"about_ca_system_score_gemma":0.0003443244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000566567,"about_ca_topic_score_gemma":0.001807983,"domain_scores_codex":[0.9999431,0.000007805151,0.000004768719,0.000009754336,0.00001744014,0.00001710435],"domain_scores_gemma":[0.9999537,0.000003501145,0.000008663607,0.000003551887,0.00001074989,0.0000198252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003190544,0.0002979914,0.0002771612,0.0002137602,0.00002224579,0.0003065082,0.00004128853,0.0004878606,0.9801957,0.0004036058,0.0004152947,0.01701966],"study_design_scores_gemma":[0.0003472099,0.00454952,0.004866964,0.0000468669,0.0001466218,0.002142128,0.0000526193,0.003669225,0.9592505,0.0002256386,0.02466137,0.00004141685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9557458,0.02150103,0.01072262,0.0004849929,0.0001123233,0.0004956286,0.001087847,0.0002996807,0.009550144],"genre_scores_gemma":[0.9677531,0.01126683,0.01235734,0.0003154084,0.00004314706,0.0001552988,0.002026153,0.00003236506,0.006050354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001500711,"threshold_uncertainty_score":0.00502032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0106856052220468,"score_gpt":0.2760195402899873,"score_spread":0.2653339350679405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}