{"id":"W2587438671","doi":"10.1021/acs.jmedchem.6b01773","title":"Replacing<scp>d</scp>-Glucosamine with Its<scp>l</scp>-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society; University of Manitoba","keywords":"Chemistry; Cytotoxic T cell; Cancer stem cell; Cancer cell; Salinomycin; Apoptosis; Cancer; Stem cell; Cancer research; Biochemistry; In vitro; Biology; Cell biology; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00121128,0.0006254318,0.001588163,0.0002358742,0.0002457143,0.0001079551,0.0004572352,0.0003674973,0.00007570353],"category_scores_gemma":[0.0005328478,0.0004453754,0.0002596165,0.000332447,0.0004861704,0.0002464308,0.0001213203,0.001539415,0.000006913615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004794659,"about_ca_system_score_gemma":0.001204965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002784045,"about_ca_topic_score_gemma":0.0001172218,"domain_scores_codex":[0.9960898,0.00009040683,0.001076473,0.000645281,0.001241756,0.0008562633],"domain_scores_gemma":[0.9956895,0.0004722413,0.001733235,0.000724113,0.000536171,0.0008447642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004835322,0.000227137,0.007597254,0.002492449,0.0005113238,0.002570091,0.001020703,0.00007914246,0.9738693,0.000001200037,0.004023615,0.007124267],"study_design_scores_gemma":[0.01015928,0.0006561779,0.004386601,0.005899018,0.000929777,0.0007021314,0.0009533191,0.0001382938,0.9480552,0.00000526631,0.02795286,0.0001620567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824928,0.01285492,0.00003008592,0.0005323964,0.001111881,0.0005015142,0.00009004267,0.00002722403,0.002359134],"genre_scores_gemma":[0.9764541,0.01296571,0.0002101557,0.0005190399,0.002585172,0.00003478673,0.000006295654,0.0001149349,0.007109827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02581407,"threshold_uncertainty_score":0.9997998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01481368204451012,"score_gpt":0.2731835833912746,"score_spread":0.2583699013467645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}