{"id":"W2587438671","doi":"10.1021/acs.jmedchem.6b01773","title":"Replacing<scp>d</scp>-Glucosamine with Its<scp>l</scp>-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society; University of Manitoba","keywords":"Chemistry; Cytotoxic T cell; Cancer stem cell; Cancer cell; Salinomycin; Apoptosis; Cancer; Stem cell; Cancer research; Biochemistry; In vitro; Biology; Cell biology; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009823692,0.0003089522,0.0001563997,0.0001071625,0.00009843187,0.0002415582,0.0002371774,0.0002158204,0.0008794591],"category_scores_gemma":[0.0001526475,0.00006012174,0.0001957454,0.0002147552,0.000222351,0.0002532648,0.0001801958,0.0003878397,0.000364556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000260824,"about_ca_system_score_gemma":0.0003572052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001094709,"about_ca_topic_score_gemma":0.001186618,"domain_scores_codex":[0.9999202,0.00002096654,0.000009121405,0.00001474187,0.00001610316,0.00001877703],"domain_scores_gemma":[0.9999001,0.0000123954,0.000036151,0.00001477423,0.00001451493,0.00002209708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002298387,0.00001839012,0.0001133082,0.00003258874,0.000006891036,0.0001002422,0.00001145505,0.0001734183,0.9961557,0.0002389644,0.0000338209,0.002885519],"study_design_scores_gemma":[0.00000865542,0.0001722353,0.0002559577,0.000003135297,0.000009919874,0.0001212677,0.00001037434,0.0002105557,0.9969235,0.000030921,0.002248523,0.000004992109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921752,0.0006601401,0.003351714,0.0001008853,0.00003173072,0.00003471242,0.0003397483,0.00005615468,0.00324973],"genre_scores_gemma":[0.9930715,0.0006389364,0.004000555,0.00007224292,0.000005955854,0.00001670676,0.0003269947,0.00003435168,0.00183279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001094709,"threshold_uncertainty_score":0.002942085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01481368204451012,"score_gpt":0.2731835833912746,"score_spread":0.2583699013467645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}