{"id":"W2587441942","doi":"10.1182/blood.v126.23.4041.4041","title":"Predictors of Response Duration and Survival with Second-Line Bosutinib Therapy in Patients (pts) with Chronic Phase Chronic Myeloid Leukemia (CML) Resistant or Intolerant to Prior Imatinib","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Bosutinib; Internal medicine; Imatinib; Cumulative incidence; Proportional hazards model; Gastroenterology; Discontinuation; Tyrosine-kinase inhibitor; Retrospective cohort study; Myeloid leukemia; Oncology; Nilotinib; Cohort; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003851216,0.0001434087,0.0002460822,0.0002089004,0.0001554194,0.000295453,0.0001482283,0.0003269756,0.001201664],"category_scores_gemma":[0.001035469,0.0001069146,0.0004381763,0.000266405,0.0001220174,0.0002973591,0.0002043058,0.0004473549,0.0001367024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001413683,"about_ca_system_score_gemma":0.0001328082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006362109,"about_ca_topic_score_gemma":0.0009204364,"domain_scores_codex":[0.9998845,0.0000316404,0.00001460089,0.0000256181,0.00001868348,0.00002502487],"domain_scores_gemma":[0.9991473,0.000255648,0.0003808813,0.00003008935,0.00003244817,0.0001536961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008807386,0.00004711813,0.9968578,0.000006252883,0.00003441875,0.0001028182,0.00001842319,0.000142912,0.0005019415,0.000009546465,0.00006114216,0.001336896],"study_design_scores_gemma":[0.00005142392,0.0006445218,0.9973134,0.000004546313,0.0000414873,0.0004781158,0.00005993208,0.001038866,0.0001456636,0.00001806329,0.0002009453,0.000002985813],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996772,0.0001023758,0.00003428841,0.00001533224,0.000001689379,0.000002405441,0.00007977534,7.694113e-7,0.00008629235],"genre_scores_gemma":[0.9996608,0.00003439101,0.0000237904,0.00001084628,0.000006879093,0.000004193796,0.00018318,5.771968e-7,0.00007516071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001201664,"threshold_uncertainty_score":0.004019976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01919849371880729,"score_gpt":0.2742516609083612,"score_spread":0.2550531671895539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}