{"id":"W2587481440","doi":"10.1093/annonc/mdw435.05","title":"Biomarker analyses from the phase 3 PALOMA-2 trial of palbociclib (P) with letrozole (L) compared with placebo (PLB) plus L in postmenopausal women with ER + /HER2– advanced breast cancer (ABC)","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; BC Cancer Agency","funders":"","keywords":"Medicine; Palbociclib; Letrozole; Internal medicine; Breast cancer; Hazard ratio; Oncology; Fulvestrant; Clinical endpoint; Population; Progression-free survival; Biomarker; Cancer; Metastatic breast cancer; Gynecology; Gastroenterology; Estrogen receptor; Tamoxifen; Clinical trial; Chemotherapy; Confidence interval; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003075316,0.0003745634,0.001316409,0.0001757047,0.00006096046,0.000006324073,0.0002647121,0.000128976,0.0004504886],"category_scores_gemma":[0.00003776427,0.000171892,0.00006013785,0.0005486053,0.001083348,0.0002240658,0.00005079239,0.0001984933,0.000003280539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002961679,"about_ca_system_score_gemma":0.0009687971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001495698,"about_ca_topic_score_gemma":0.00267234,"domain_scores_codex":[0.9975509,0.0002492802,0.0006129544,0.0004977193,0.000476097,0.00061305],"domain_scores_gemma":[0.9973814,0.0006663435,0.0007045812,0.0005958146,0.0004677047,0.0001841759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7684271,0.001480047,0.008628198,0.00003697808,0.001591584,0.0001411564,0.00149445,0.0001762057,0.06033,0.0000181621,0.0001752747,0.1575008],"study_design_scores_gemma":[0.6938983,0.05260884,0.209479,0.00159935,0.0005640784,0.0002625396,0.005157797,0.00005212867,0.02421521,0.0002059561,0.01122682,0.0007298944],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987764,0.000778765,0.00036059,0.008843767,0.00008195139,0.001151543,0.0005049829,0.0000348484,0.0004795505],"genre_scores_gemma":[0.9969664,0.0001745949,0.0009618172,0.00110836,0.0001484013,0.000408134,0.00002659814,0.00006009701,0.0001456045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2008509,"threshold_uncertainty_score":0.7009551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08366119973742049,"score_gpt":0.4202396635614648,"score_spread":0.3365784638240443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}