{"id":"W2587481440","doi":"10.1093/annonc/mdw435.05","title":"Biomarker analyses from the phase 3 PALOMA-2 trial of palbociclib (P) with letrozole (L) compared with placebo (PLB) plus L in postmenopausal women with ER + /HER2– advanced breast cancer (ABC)","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; BC Cancer Agency","funders":"","keywords":"Medicine; Palbociclib; Letrozole; Internal medicine; Breast cancer; Hazard ratio; Oncology; Fulvestrant; Clinical endpoint; Population; Progression-free survival; Biomarker; Cancer; Metastatic breast cancer; Gynecology; Gastroenterology; Estrogen receptor; Tamoxifen; Clinical trial; Chemotherapy; Confidence interval; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001842541,0.001253684,0.001835207,0.0004196327,0.0003377623,0.0009925961,0.0005596584,0.0009558161,0.00432193],"category_scores_gemma":[0.002282277,0.0004323456,0.002136786,0.0005768921,0.0004648708,0.0008513952,0.0004450744,0.00228306,0.00074745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000725548,"about_ca_system_score_gemma":0.00109716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009087568,"about_ca_topic_score_gemma":0.002829591,"domain_scores_codex":[0.9994273,0.000277359,0.00003426533,0.0001008367,0.00007952717,0.0000806669],"domain_scores_gemma":[0.9991754,0.000238029,0.0002265195,0.00007911804,0.00008640924,0.0001946063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8931454,0.003135193,0.01579995,0.0009568786,0.00739762,0.0001216025,0.00008605987,0.00105198,0.01091996,0.0002146659,0.007142376,0.06002824],"study_design_scores_gemma":[0.7236536,0.1295255,0.1069816,0.0001925431,0.01700306,0.0005657485,0.0001673739,0.001576821,0.004770678,0.001465414,0.01399147,0.0001063169],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705659,0.0134225,0.000762952,0.001745086,0.0003144582,0.001043134,0.008955782,0.0002023935,0.002987709],"genre_scores_gemma":[0.9785249,0.003092059,0.00137115,0.001884717,0.0002755315,0.001510371,0.01115011,0.00004144144,0.002149681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00432193,"threshold_uncertainty_score":0.0144583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08366119973742049,"score_gpt":0.4202396635614648,"score_spread":0.3365784638240443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}