{"id":"W2587520109","doi":"10.1182/blood.v120.21.545.545","title":"High Incidence of EZH2 Mutations with Variable Mutation Load in Follicular Lymphoma and Its Consequences for EZH2 Targeted Therapy","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"EZH2; Biology; Genetics; Histone; Histone methyltransferase; Mutation; Cancer research; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000156481,0.00008958262,0.0001063641,0.00003833041,0.00003805456,0.000007323369,0.00004733308,0.000102603,0.00000534279],"category_scores_gemma":[0.00005840413,0.00008136907,0.00002027527,0.0001383948,0.00005719374,0.00001455264,0.00001108717,0.00001851904,4.479052e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001648367,"about_ca_system_score_gemma":0.0001747244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001361541,"about_ca_topic_score_gemma":0.00008553356,"domain_scores_codex":[0.9994028,0.00003316715,0.0001575139,0.0001614988,0.00009755912,0.0001474698],"domain_scores_gemma":[0.999583,0.00002270038,0.0001082415,0.0001040908,0.0001454052,0.00003656625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001423701,0.0001638534,0.006882572,0.00002590404,0.00009079091,7.835422e-7,0.00021659,0.001090126,0.9899633,0.0004480022,0.00001458555,0.0009611037],"study_design_scores_gemma":[0.003265755,0.0003530634,0.02910571,0.00002939515,0.00004934028,0.00003718441,0.00005879485,0.0001987542,0.9662141,0.0002884732,0.0002703927,0.0001290108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992281,0.005757831,0.001431512,0.0000514136,0.00004557996,0.0003767934,0.00002606251,0.000006334628,0.00002343914],"genre_scores_gemma":[0.9955574,0.0001633739,0.003932145,0.00002536778,0.0000602816,0.00008888764,0.0001244227,0.0000117974,0.00003638293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02374919,"threshold_uncertainty_score":0.3318134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00738874545718747,"score_gpt":0.2308877728415228,"score_spread":0.2234990273843353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}