{"id":"W2587520109","doi":"10.1182/blood.v120.21.545.545","title":"High Incidence of EZH2 Mutations with Variable Mutation Load in Follicular Lymphoma and Its Consequences for EZH2 Targeted Therapy","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"EZH2; Biology; Genetics; Histone; Histone methyltransferase; Mutation; Cancer research; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003315696,0.0001134399,0.0002809423,0.0005461323,0.0002401215,0.0003689345,0.0002244857,0.0003516159,0.001777484],"category_scores_gemma":[0.001252328,0.00009537934,0.0001339807,0.0003901632,0.0002923072,0.0002474975,0.0001982048,0.0003651097,0.0002356138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002905362,"about_ca_system_score_gemma":0.0001130767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006508584,"about_ca_topic_score_gemma":0.0005897853,"domain_scores_codex":[0.9997639,0.00004611243,0.00001905609,0.00005180951,0.00006234627,0.00005675864],"domain_scores_gemma":[0.9992207,0.000280295,0.0002248677,0.00006673863,0.0000622248,0.0001452102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001928507,0.0001192935,0.9234595,0.0000304544,0.00005440378,0.0109526,0.0001645409,0.0003484114,0.03621827,0.0002188146,0.0004400344,0.02606516],"study_design_scores_gemma":[0.00003304553,0.000606923,0.9591982,0.000008234058,0.00007159534,0.03075564,0.000320951,0.001359295,0.006395794,0.0004872424,0.0007520905,0.00001112748],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989946,0.0002233466,0.0001958839,0.00004881919,0.000002054432,0.000005144057,0.00004524645,0.00001101016,0.0004738747],"genre_scores_gemma":[0.9998347,0.00002944974,0.00004298447,0.000009568318,0.000003285717,8.776938e-7,0.00002728434,0.000002476767,0.00004927018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001777484,"threshold_uncertainty_score":0.005946219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00738874545718747,"score_gpt":0.2308877728415228,"score_spread":0.2234990273843353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}