{"id":"W2587523829","doi":"10.1038/ncomms14175","title":"Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Simon Fraser University; BC Cancer Agency","funders":"National Center for Advancing Translational Sciences; National Center for Chronic Disease Prevention and Health Promotion; National Institute of Environmental Health Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Cancer Council NSW; National Human Genome Research Institute; Cancer Council Victoria; Medical Research Council; University of Texas MD Anderson Cancer Center; Institut National Du Cancer; Centers for Disease Control and Prevention; National Institutes of Health; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; U.S. Public Health Service; University at Buffalo; Regione Autonoma della Sardegna; Associazione Italiana per la Ricerca sul Cancro; University of Utah; Fondation de France; Generalitat de Catalunya; Canadian Institutes of Health Research; Bundesamt für Strahlenschutz; MedStar Health Research Institute; Cancerfonden; Ministerio de Economía y Competitividad; Bundesministerium für Bildung und Forschung; University of Sydney; Division of Cancer Prevention, National Cancer Institute; Health Research Board; National Health and Medical Research Council; Leukemia and Lymphoma Research; Stockholms Läns Landsting; University of Pittsburgh; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Huntsman Cancer Institute; José Carreras Leukämie-Stiftung; Wellcome Trust; Memorial Sloan-Kettering Cancer Center; Yale University; Karolinska Institutet; Utah State University; European Commission; U.S. Department of Veterans Affairs; Compagnia di San Paolo; Leukemia and Lymphoma Society; Utah Department of Health; Brigham and Women's Hospital; University of California, San Francisco; U.S. Department of Health and Human Services; Instituto de Salud Carlos III; Wake Forest University; Ohio State University; Cancer Research UK; World Health Organization; University of Southern California; American Cancer Society; Michael Smith Health Research BC","keywords":"Gene; Genetics; Biology; Immune dysregulation; Genome; Transcription factor; Genome-wide association study; Immune system; Chromatin; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00104186,0.00017156,0.000541543,0.0005474097,0.0004866641,0.000068788,0.001642976,0.0005260557,0.00005338505],"category_scores_gemma":[0.00251168,0.00016926,0.0002520185,0.0008893491,0.0002688808,0.0002777693,0.0007294948,0.0008721289,0.00002555122],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.06377085,"about_ca_system_score_gemma":0.007334094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003527695,"about_ca_topic_score_gemma":0.008713667,"domain_scores_codex":[0.9980977,0.0002217957,0.0005621234,0.0002703328,0.0004982934,0.0003497488],"domain_scores_gemma":[0.9922664,0.001105082,0.0006265455,0.005355874,0.0005448359,0.0001012346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000144173,0.0002570834,0.9691755,0.0002017018,0.001864902,0.000007011484,0.0005002466,0.0023567,0.01997296,0.001553968,0.0002814238,0.003684327],"study_design_scores_gemma":[0.004151118,0.00004566908,0.9443295,0.00006084577,0.000594486,0.000005142412,0.00005073184,0.04485082,0.002504925,0.0002149247,0.003046718,0.0001451228],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980801,0.01171976,0.00005680007,0.002749782,0.00004595763,0.0005883686,0.0000367567,0.0000474111,0.003954147],"genre_scores_gemma":[0.9949931,0.002960917,0.0009832776,0.00008510682,0.00005389609,0.00007341006,0.000438376,0.00002363797,0.0003882684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05643676,"threshold_uncertainty_score":0.9982934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02890777478110752,"score_gpt":0.3599301205812248,"score_spread":0.3310223458001172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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