{"id":"W2587523829","doi":"10.1038/ncomms14175","title":"Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Simon Fraser University; BC Cancer Agency","funders":"National Center for Advancing Translational Sciences; National Center for Chronic Disease Prevention and Health Promotion; National Institute of Environmental Health Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Cancer Council NSW; National Human Genome Research Institute; Cancer Council Victoria; Medical Research Council; University of Texas MD Anderson Cancer Center; Institut National Du Cancer; Centers for Disease Control and Prevention; National Institutes of Health; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; U.S. Public Health Service; University at Buffalo; Regione Autonoma della Sardegna; Associazione Italiana per la Ricerca sul Cancro; University of Utah; Fondation de France; Generalitat de Catalunya; Canadian Institutes of Health Research; Bundesamt für Strahlenschutz; MedStar Health Research Institute; Cancerfonden; Ministerio de Economía y Competitividad; Bundesministerium für Bildung und Forschung; University of Sydney; Division of Cancer Prevention, National Cancer Institute; Health Research Board; National Health and Medical Research Council; Leukemia and Lymphoma Research; Stockholms Läns Landsting; University of Pittsburgh; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Huntsman Cancer Institute; José Carreras Leukämie-Stiftung; Wellcome Trust; Memorial Sloan-Kettering Cancer Center; Yale University; Karolinska Institutet; Utah State University; European Commission; U.S. Department of Veterans Affairs; Compagnia di San Paolo; Leukemia and Lymphoma Society; Utah Department of Health; Brigham and Women's Hospital; University of California, San Francisco; U.S. Department of Health and Human Services; Instituto de Salud Carlos III; Wake Forest University; Ohio State University; Cancer Research UK; World Health Organization; University of Southern California; American Cancer Society; Michael Smith Health Research BC","keywords":"Gene; Genetics; Biology; Immune dysregulation; Genome; Transcription factor; Genome-wide association study; Immune system; Chromatin; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002585081,0.0005251284,0.0007998614,0.001855305,0.0004763676,0.001217762,0.0005527131,0.0006007949,0.002416807],"category_scores_gemma":[0.003398836,0.0002910094,0.002162837,0.00270167,0.0003862234,0.0002865993,0.0006458354,0.0005958771,0.0001635606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002900444,"about_ca_system_score_gemma":0.000296772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003977019,"about_ca_topic_score_gemma":0.004301331,"domain_scores_codex":[0.9983456,0.0005507567,0.0001582339,0.000555355,0.000263559,0.0001263294],"domain_scores_gemma":[0.9976479,0.0011924,0.0005162681,0.0003331047,0.000190479,0.0001198153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001117983,0.00003386295,0.9602465,0.0003317685,0.01372623,0.0003763437,0.00009089903,0.0005846133,0.01217976,0.000139706,0.0004999234,0.01067253],"study_design_scores_gemma":[0.0001201102,0.000202507,0.9835241,0.0000796267,0.0105364,0.0006705422,0.0001109171,0.00105537,0.001599093,0.0004843467,0.001603522,0.00001342148],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.965882,0.02770199,0.00338081,0.0005008829,0.0001129596,0.00001831083,0.001319364,0.0000961808,0.0009874221],"genre_scores_gemma":[0.9975621,0.001413604,0.0004257782,0.00007672879,0.0000444827,0.000008175346,0.0002841778,0.00001060095,0.0001744637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003977019,"threshold_uncertainty_score":0.0136714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02890777478110752,"score_gpt":0.3599301205812248,"score_spread":0.3310223458001172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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