{"id":"W2587599577","doi":"10.1093/neuonc/now212.018","title":"ACTR-19. BASELINE PLASMA MATRIX METALLOPROTEINASE 9 (MMP9) PREDICTS OVERALL SURVIVAL (OS) BENEFIT FROM BEVACIZUMAB INDEPENDENTLY OF MOLECULAR SUBTYPES IN NEWLY DIAGNOSED GLIOBLASTOMA: RETROSPECTIVE ANALYSIS OF AVAglio","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Princess Margaret Cancer Centre","funders":"","keywords":"Bevacizumab; Temozolomide; Medicine; Internal medicine; Placebo; Oncology; MMP9; MMP2; Univariate analysis; Post-hoc analysis; Retrospective cohort study; Gastroenterology; Multivariate analysis; Chemotherapy; Pathology; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004955615,0.0004539449,0.002034143,0.001297471,0.0000386592,0.0000104341,0.0002903069,0.0004275158,0.0007371322],"category_scores_gemma":[0.001492915,0.0003444937,0.0005638525,0.001265746,0.0001891987,0.0001412687,0.000192428,0.0003116173,0.00002337533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006760896,"about_ca_system_score_gemma":0.0003649036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001794594,"about_ca_topic_score_gemma":0.005462734,"domain_scores_codex":[0.9961588,0.0004375494,0.001109814,0.0009298002,0.0008254605,0.0005385763],"domain_scores_gemma":[0.9960179,0.001725622,0.0007077646,0.0008455992,0.0003601891,0.0003429322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004168723,0.003301265,0.3263068,0.00004238454,0.003188561,0.004479457,0.0002710952,0.0004527835,0.652921,0.0005870463,0.0001377003,0.00414318],"study_design_scores_gemma":[0.02868764,0.005631723,0.4228247,0.0001274754,0.005288289,0.00003373448,0.00009408076,0.0009029547,0.5348707,0.0004010915,0.0007928757,0.0003447644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956136,0.0004319003,0.0001106385,0.001522588,0.0002518714,0.0009870139,0.0007399254,0.00005484489,0.0002876418],"genre_scores_gemma":[0.9986486,0.0003219905,0.0004269124,0.0001792314,0.00007684067,0.0001553066,0.0001108931,0.00005742488,0.00002273085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1180504,"threshold_uncertainty_score":0.9999007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112914385499897,"score_gpt":0.273743561139056,"score_spread":0.262614417284057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}