{"id":"W2587615733","doi":"10.1182/blood.v126.23.443.443","title":"Targeting MTHFD2 in Acute Myeloid Leukemia","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"","keywords":"Gene knockdown; Myeloid; Cancer research; Myeloid leukemia; Biology; Retinoic acid; Leukemia; Tretinoin; Acute promyelocytic leukemia; Cell growth; Cellular differentiation; Cell culture; Downregulation and upregulation; Molecular biology; Immunology; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001256416,0.0002911527,0.0002604456,0.0001841101,0.0001561346,0.0002170039,0.0001558166,0.0002973109,0.00103928],"category_scores_gemma":[0.00008236746,0.000123881,0.0001837422,0.0001738139,0.0001579722,0.00009583949,0.0001166695,0.0004396887,0.0003708438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003781655,"about_ca_system_score_gemma":0.0001617406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005105576,"about_ca_topic_score_gemma":0.0008500998,"domain_scores_codex":[0.9998918,0.00001230417,0.000009263474,0.0000265227,0.00003701632,0.00002306691],"domain_scores_gemma":[0.9999603,0.000008320958,0.00001179675,0.000004382203,0.000006092215,0.000009110538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001232637,0.0000231908,0.0002200391,0.00005123668,0.000005882518,0.00003356702,0.000006123756,0.00009725655,0.9971175,0.00006920386,0.0001328909,0.002119878],"study_design_scores_gemma":[0.00003537295,0.0002534149,0.002645521,0.000005111396,0.00002040598,0.0003168575,0.00001163998,0.0009463363,0.9866584,0.00004853596,0.009055389,0.000003028477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801574,0.00637158,0.008967839,0.0003855916,0.0001325482,0.0001025669,0.001741309,0.0002824742,0.001858741],"genre_scores_gemma":[0.9887632,0.001943468,0.004393096,0.00009735135,0.00001870207,0.00006205752,0.001300724,0.00002385602,0.003397502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00103928,"threshold_uncertainty_score":0.003476679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02603047317062827,"score_gpt":0.2961985301848284,"score_spread":0.2701680570142001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}