{"id":"W2587637943","doi":"10.1002/cncr.30579","title":"Determinants of the recommended phase 2 dose of molecular targeted agents","year":2017,"lang":"en","type":"review","venue":"Cancer","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Dosing; Internal medicine; Clinical endpoint; Pharmacokinetics; Pharmacodynamics; Confidence interval; Odds ratio; Surrogate endpoint; Oncology; Clinical trial; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.001542157,0.0003082812,0.003159737,0.00004545026,0.00004653139,0.0000101936,0.001111893,0.0003652677,0.0006686249],"category_scores_gemma":[0.05096793,0.0001838686,0.0008749501,0.0001273682,0.000226644,0.00001873322,0.0002755586,0.0003509204,0.000005534192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007338358,"about_ca_system_score_gemma":0.0003618863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001171019,"about_ca_topic_score_gemma":0.000003005353,"domain_scores_codex":[0.9962255,0.001179302,0.001720096,0.0003235388,0.0003282256,0.0002233471],"domain_scores_gemma":[0.9865524,0.008598573,0.003080226,0.001550711,0.0001372955,0.00008083511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001505982,0.0001357695,0.00000321513,0.01597896,0.0001930211,0.000007677805,0.00001240226,1.951641e-8,0.000004920694,0.0004482136,0.001641782,0.981559],"study_design_scores_gemma":[0.001649293,0.00009909786,0.000006436022,0.03871211,0.003492621,0.000003205514,0.000002172396,0.000009882292,0.001109283,0.148493,0.8060462,0.000376747],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000671756,0.99393,0.0004680572,0.00001477042,0.001995536,0.001472522,0.001446135,0.0000122038,0.0005936174],"genre_scores_gemma":[0.00001690769,0.9501204,0.04914191,0.00003006675,0.0001264082,0.0001791615,0.000002051898,0.00006515568,0.0003179589],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9811822,"threshold_uncertainty_score":0.9570262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8369433527983116,"score_gpt":0.7032770405706433,"score_spread":0.1336663122276682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}