{"id":"W2587660016","doi":"10.1093/ecco-jcc/jjx002.585","title":"P460 Early use of therapeutic drug monitoring to individualize infliximab therapy in paediatric IBD: a multicentre prospective COHORT study","year":2017,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Manitoba; Alberta Children's Hospital; Children's Hospital of Eastern Ontario; Dalhousie University; BC Children's Hospital; Janeway Children's Health and Rehabilitation Centre; McMaster Children's Hospital; Hospital for Sick Children","funders":"","keywords":"Medicine; Infliximab; Therapeutic drug monitoring; Prospective cohort study; Drug; Pharmacotherapy; Cohort study; Pediatrics; Intensive care medicine; Internal medicine; Pharmacology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002137832,0.0004972775,0.0005023908,0.0007120669,0.0006226301,0.001223832,0.00073736,0.0005476355,0.002331193],"category_scores_gemma":[0.004544079,0.0005426821,0.00113245,0.001717278,0.0004516687,0.0008256756,0.000858317,0.001044965,0.0003958904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006558644,"about_ca_system_score_gemma":0.0009536427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009147269,"about_ca_topic_score_gemma":0.009118246,"domain_scores_codex":[0.9978824,0.0006025115,0.0002287873,0.0004869093,0.0004775654,0.0003218047],"domain_scores_gemma":[0.9952721,0.0005026592,0.002836254,0.0004844145,0.0004578019,0.0004467898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001791103,0.00002466382,0.998585,0.0000180199,0.00006445153,0.00008032536,0.00008865002,0.00002397145,0.00006074656,0.00001530508,0.0001261384,0.0007336414],"study_design_scores_gemma":[0.00002208625,0.0002537105,0.9985869,0.0000203995,0.00006044842,0.0003959962,0.0001771906,0.0001179777,0.00004141429,0.00001094181,0.0003073225,0.000005666407],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980502,0.0004011427,0.0001852555,0.00004359962,0.00001255486,0.00003717977,0.0008707177,0.000004039035,0.0003952549],"genre_scores_gemma":[0.9987733,0.0002025425,0.0002039505,0.00003583263,0.00001205853,0.00003852692,0.0005976105,0.000005868312,0.0001303787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009147269,"threshold_uncertainty_score":0.018188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0178954624490926,"score_gpt":0.2725362403300294,"score_spread":0.2546407778809368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}