{"id":"W2587686129","doi":"10.1038/nature21356","title":"Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity","year":2017,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":898,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute","keywords":"Extrachromosomal DNA; Biology; Metaphase; Oncogene; Genetics; Genome; Gene; Cancer; Human genetics; Chromosome; Human genome; Computational biology; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007957037014134033,"score_gpt":0.2682529062328649,"score_spread":0.2602958692187309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}