{"id":"W2587706314","doi":"10.1016/j.ymthe.2017.01.018","title":"Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer’s Disease","year":2017,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"Program for Changjiang Scholars and Innovative Research Team in University; Huazhong University of Science and Technology; National Natural Science Foundation of China","keywords":"Histone deacetylase 2; Tauopathy; Small interfering RNA; Ectopic expression; Biology; AMPK; Cell biology; HDAC1; Histone; Epigenetics; Histone deacetylase; Gene silencing; GSK-3; Cancer research; Kinase; Protein kinase A; Transfection; Genetics; Medicine; Neurodegeneration; Disease; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001842174,0.0006463881,0.0006792986,0.0003900359,0.0002502691,0.0003053032,0.000383877,0.000503191,0.001612399],"category_scores_gemma":[0.00009219755,0.0002760918,0.0004688717,0.0001846127,0.0002794799,0.0002279639,0.0001997678,0.0008866353,0.0008138988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000306305,"about_ca_system_score_gemma":0.0002960717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007978248,"about_ca_topic_score_gemma":0.00125767,"domain_scores_codex":[0.9998341,0.00001783889,0.00002772406,0.0000330525,0.00004559666,0.00004161803],"domain_scores_gemma":[0.9999259,0.000005483806,0.00002031073,0.00001126998,0.00000945071,0.00002775457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002349847,0.00008864928,0.0001014396,0.00007370895,0.00001440057,0.00006232142,0.000008461865,0.00007160398,0.9972489,0.00007090015,0.000128159,0.001896269],"study_design_scores_gemma":[0.0001308136,0.0008043462,0.004414064,0.00001636392,0.00007296324,0.0004282084,0.0000524341,0.001757947,0.9856463,0.0001296547,0.00653266,0.00001436015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830469,0.005382608,0.005553229,0.0003560238,0.0002895986,0.0001073469,0.001058106,0.0006513851,0.00355477],"genre_scores_gemma":[0.9873125,0.002584278,0.003560917,0.0001674638,0.00002967745,0.0001099764,0.001282052,0.00008036459,0.004872713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001612399,"threshold_uncertainty_score":0.005393982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03427970209850582,"score_gpt":0.3173120223548428,"score_spread":0.283032320256337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}