{"id":"W2587728357","doi":"10.1182/blood.v106.11.1002.1002","title":"Clonotypic IgG B Cells in Waldenstrom Macroglobulinemia Cells Are Derived from Multiple Post-Transformed B Cells That Have Undergone Isotype Switch Recombination.","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Immunoglobulin class switching; Biology; Waldenstrom macroglobulinemia; Macroglobulinemia; Isotype; Somatic hypermutation; Molecular biology; Cytidine deaminase; Immunoglobulin M; Antibody; B cell; Immunoglobulin heavy chain; Immunoglobulin gene; Genetics; Immunology; Multiple myeloma; Immunoglobulin G; Monoclonal antibody; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009844801,0.0001728601,0.00008994715,0.0002406739,0.0001262245,0.0001199036,0.0001149154,0.0001597584,0.001294654],"category_scores_gemma":[0.0001241933,0.00009694709,0.0001222252,0.0001144066,0.0001177845,0.00006141952,0.000158583,0.0002198276,0.0003768793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001286365,"about_ca_system_score_gemma":0.00008392623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004961972,"about_ca_topic_score_gemma":0.0009320314,"domain_scores_codex":[0.9999056,0.00001483069,0.000007240473,0.00001658754,0.00002718179,0.00002849284],"domain_scores_gemma":[0.9998984,0.00002481639,0.00002297545,0.00001603798,0.000009124643,0.0000284689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005616752,0.00001294928,0.002309741,0.00001348149,0.000003665276,0.0001465401,0.0000208133,0.00001934353,0.9960829,0.00007151077,0.00002153063,0.001241411],"study_design_scores_gemma":[0.00003809645,0.00100598,0.163117,0.00001433202,0.00004447594,0.004122551,0.00009878961,0.001014007,0.8244883,0.0001820738,0.005867659,0.000006640531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983391,0.0001499654,0.0006973641,0.000008262604,0.000003567515,0.00001120829,0.0001020753,0.00002734512,0.0006612132],"genre_scores_gemma":[0.9972159,0.00008699579,0.0009616094,0.00001564281,0.000004099625,0.00001889889,0.0005965141,0.000008221256,0.001092068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001294654,"threshold_uncertainty_score":0.004330993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01643063475570199,"score_gpt":0.251248842654087,"score_spread":0.234818207898385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}