{"id":"W2587729638","doi":"10.1182/blood.v122.21.346.346","title":"Characterization Of The Effects Of Mutated EZH2 On Expression and Epigenome In a Mouse Lymphoma Model","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"","keywords":"Biology; H3K4me3; Germinal center; Epigenome; Cancer research; Molecular biology; Lymphoma; Carcinogenesis; EZH2; Epigenetics; Gene expression; Gene; B cell; DNA methylation; Genetics; Antibody; Promoter; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002347353,0.0005003929,0.000320033,0.0008342667,0.0001441327,0.0003002661,0.0002683922,0.000312744,0.001536745],"category_scores_gemma":[0.0001278044,0.0002098657,0.0003318157,0.0002380948,0.0002249013,0.0001721663,0.0002351172,0.0007032118,0.0003789015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003299381,"about_ca_system_score_gemma":0.0001145711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006086195,"about_ca_topic_score_gemma":0.0009440387,"domain_scores_codex":[0.9997633,0.00003178966,0.00001658037,0.00005956698,0.00007688291,0.00005190701],"domain_scores_gemma":[0.9997801,0.00004054478,0.00005278569,0.000030733,0.00002415244,0.0000716216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003796853,0.00001864635,0.0001925621,0.000006968435,0.00000366431,0.00001637368,0.000005039632,0.00002614386,0.9993774,0.00001685796,0.000008744594,0.0002895732],"study_design_scores_gemma":[0.00001209931,0.0002426479,0.005280901,0.00000178289,0.00001803164,0.0001348375,0.00001250353,0.0006549159,0.9930142,0.00002269911,0.0006028675,0.000002700422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880182,0.0006842159,0.009136932,0.00006926533,0.00001567969,0.00005996199,0.00104803,0.0002210085,0.0007467801],"genre_scores_gemma":[0.9899402,0.0004844824,0.004472733,0.00006236082,0.000009276413,0.0001342649,0.001627285,0.00008670172,0.003182664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001536745,"threshold_uncertainty_score":0.00514096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004139031775691935,"score_gpt":0.195397945452689,"score_spread":0.191258913676997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}