{"id":"W2587740521","doi":"10.1073/pnas.1617244114","title":"Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in <i>PIK3CD</i> and <i>PIK3R1</i>","year":2017,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Yale University","keywords":"PI3K/AKT/mTOR pathway; Mutant; P110α; Chemistry; APDS; Biology; Molecular biology; Cell biology; Gene; Biochemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001077227,0.0001859247,0.000105433,0.00009613505,0.000104135,0.0001661032,0.0001992489,0.0001925667,0.001336975],"category_scores_gemma":[0.0001359203,0.0001012002,0.0001959632,0.0000916483,0.0002243945,0.0001139078,0.0001299442,0.0003380874,0.0002482081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004065425,"about_ca_system_score_gemma":0.0001212716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007126919,"about_ca_topic_score_gemma":0.0009279365,"domain_scores_codex":[0.9999201,0.00001524308,0.0000102823,0.00001364609,0.00002046367,0.00002017363],"domain_scores_gemma":[0.9999433,0.00001057698,0.0000214138,0.000005222435,0.000004599734,0.00001487247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001840012,0.0000207719,0.0007014825,0.00001570979,0.00000885885,0.000114188,0.000008079002,0.0001884526,0.9975634,0.0001492148,0.00009488597,0.0009510716],"study_design_scores_gemma":[0.00006317735,0.0001769306,0.01674844,0.000006544371,0.00001635194,0.001218134,0.00003539416,0.003146191,0.9770882,0.00016604,0.001324689,0.000009999408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982806,0.0002037277,0.0005223477,0.00007129029,0.00001519467,0.000005469476,0.0001406703,0.00002381876,0.0007368742],"genre_scores_gemma":[0.9993356,0.00007448603,0.0002551481,0.00003963865,0.000002032674,0.000004404475,0.0000837675,0.000005858556,0.0001991244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001336975,"threshold_uncertainty_score":0.004472554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01958382125762266,"score_gpt":0.2821581986038655,"score_spread":0.2625743773462429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}