{"id":"W2587804655","doi":"10.1016/j.jacc.2016.11.056","title":"Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease","year":2017,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":266,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Canadian Heart Research Centre; University of Ottawa; Montreal Heart Institute","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Medical Research Council; National Institute for Health and Care Research; British Heart Foundation; Wellcome Trust","keywords":"Medicine; Pleiotropy; Coronary artery disease; Internal medicine; Cardiology; Disease; Genetics; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001897785,0.000111921,0.0007533737,0.00004868105,0.0001067929,0.000004731019,0.000468674,0.00006350139,0.000003414536],"category_scores_gemma":[0.002888827,0.00007001284,0.0003150325,0.00005903402,0.0006198123,0.000005999936,0.000102845,0.00008567492,4.13751e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004324172,"about_ca_system_score_gemma":0.000327474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005742966,"about_ca_topic_score_gemma":0.00001992267,"domain_scores_codex":[0.9976722,0.001176181,0.0005744206,0.0001221603,0.0003071684,0.0001478695],"domain_scores_gemma":[0.995177,0.0001163271,0.003216785,0.000577125,0.0008600412,0.00005266892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009362446,0.0001009951,0.9450029,0.0002681804,0.004748821,0.00003287016,0.00006093731,0.01019715,0.03263237,0.00004975001,0.005710787,0.0002590013],"study_design_scores_gemma":[0.0008702311,0.0006172608,0.9955266,0.0002380013,0.0009553378,0.000134951,0.0003948431,0.0002292151,0.0005139265,0.0003934046,0.0000360239,0.00009017234],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976202,0.0006374466,0.0004349272,0.0006099429,0.0002163066,0.0002481897,0.00007775466,9.53425e-7,0.0001542463],"genre_scores_gemma":[0.9994237,0.00009711045,0.0001379167,0.00005407299,0.0001263704,0.000009491702,0.000005432177,0.00001130701,0.000134639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05052373,"threshold_uncertainty_score":0.3458405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674152777527535,"score_gpt":0.2790611538911986,"score_spread":0.2623196261159232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}