{"id":"W2587804655","doi":"10.1016/j.jacc.2016.11.056","title":"Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease","year":2017,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":266,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Canadian Heart Research Centre; University of Ottawa; Montreal Heart Institute","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Medical Research Council; National Institute for Health and Care Research; British Heart Foundation; Wellcome Trust","keywords":"Medicine; Pleiotropy; Coronary artery disease; Internal medicine; Cardiology; Disease; Genetics; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002377091,0.0007027874,0.0006777414,0.00190138,0.0006542419,0.0006128629,0.0004234286,0.0004318789,0.002903938],"category_scores_gemma":[0.002578481,0.0002226508,0.001232231,0.001944283,0.000610049,0.0002274151,0.0009386721,0.0006194875,0.0002854246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000194371,"about_ca_system_score_gemma":0.0004938215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008645242,"about_ca_topic_score_gemma":0.002379364,"domain_scores_codex":[0.9986998,0.0003866508,0.0001402717,0.0004530917,0.0002064077,0.000113777],"domain_scores_gemma":[0.9962032,0.001700112,0.001095562,0.0003949146,0.0002423401,0.0003638886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001215817,0.00007915588,0.9386827,0.0001658909,0.001158042,0.001112503,0.0002742996,0.0004881592,0.04382398,0.0001902057,0.0002134237,0.01259596],"study_design_scores_gemma":[0.00006970824,0.0001870543,0.9943264,0.00002096185,0.0004904274,0.001293645,0.00008488312,0.0004880632,0.002184132,0.0002984631,0.0005432294,0.0000130516],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957954,0.0007122252,0.002215214,0.00007201944,0.000009692231,0.00002349919,0.0006782206,0.00003580732,0.0004579212],"genre_scores_gemma":[0.9960508,0.0002204099,0.002625617,0.00005154153,0.00001407116,0.00002423932,0.000815319,0.00001993357,0.000178075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002903938,"threshold_uncertainty_score":0.01257139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674152777527535,"score_gpt":0.2790611538911986,"score_spread":0.2623196261159232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}