{"id":"W2587821175","doi":"10.1038/srep42270","title":"Neuronally-directed effects of RXR activation in a mouse model of Alzheimer’s disease","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Weston Brain Institute","keywords":"Bexarotene; Synaptophysin; Astrogliosis; Excitotoxicity; Subiculum; Neuroscience; Retinoid X receptor; Neuron; Agonist; Biology; Alzheimer's disease; Internal medicine; Hippocampus; Glutamate receptor; Endocrinology; Medicine; Receptor; Disease; Dentate gyrus; Central nervous system; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003751465,0.0009878653,0.0006873528,0.0009588064,0.0003231545,0.0004401089,0.0004031442,0.0008559239,0.001205237],"category_scores_gemma":[0.00009874708,0.0003366832,0.0005311604,0.0003513128,0.000512118,0.0004184738,0.0002436567,0.001889046,0.0004414039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003898141,"about_ca_system_score_gemma":0.0003357178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008900597,"about_ca_topic_score_gemma":0.001458265,"domain_scores_codex":[0.9996865,0.00005646358,0.00004621945,0.00006784269,0.00007740626,0.00006559323],"domain_scores_gemma":[0.9998531,0.00001122814,0.00004742455,0.00002615316,0.00001510157,0.00004694379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004077551,0.0002227644,0.0001148818,0.00004168274,0.000009941014,0.00009244784,0.00002892507,0.00005636626,0.9979433,0.0001322336,0.00004522678,0.0009043523],"study_design_scores_gemma":[0.000179983,0.003397209,0.003831582,0.00002690298,0.00006369437,0.0004017242,0.00005733989,0.0006429853,0.9884363,0.0001895953,0.002758824,0.00001378754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922651,0.00190868,0.002706765,0.0002704591,0.00009275709,0.0001090018,0.0007419091,0.0002214056,0.001683953],"genre_scores_gemma":[0.9810839,0.003480882,0.006080868,0.0001674392,0.00003096251,0.0002903705,0.001055607,0.0000436958,0.007766288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001205237,"threshold_uncertainty_score":0.004031897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412967913148053,"score_gpt":0.2572703159058554,"score_spread":0.2431406367743749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}