{"id":"W2587821175","doi":"10.1038/srep42270","title":"Neuronally-directed effects of RXR activation in a mouse model of Alzheimer’s disease","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Weston Brain Institute","keywords":"Bexarotene; Synaptophysin; Astrogliosis; Excitotoxicity; Subiculum; Neuroscience; Retinoid X receptor; Neuron; Agonist; Biology; Alzheimer's disease; Internal medicine; Hippocampus; Glutamate receptor; Endocrinology; Medicine; Receptor; Disease; Dentate gyrus; Central nervous system; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003070977,0.00009220716,0.0001354947,0.00006163244,0.00009662601,0.00003868166,0.0001826405,0.00006505854,0.000002527218],"category_scores_gemma":[0.0007015951,0.00008692025,0.00007092905,0.00005467109,0.000246884,0.00001257226,0.0001121014,0.00004656426,3.35579e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006102234,"about_ca_system_score_gemma":0.0002584999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001620889,"about_ca_topic_score_gemma":0.00000375253,"domain_scores_codex":[0.998908,0.00002765242,0.000303314,0.0004054298,0.0002227651,0.0001328495],"domain_scores_gemma":[0.9983459,0.000006632517,0.0004724546,0.0009638325,0.0001503877,0.00006081478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003239539,0.00008483634,0.006278329,0.0001063977,0.00001266865,0.00001138166,0.00003097004,0.0006243302,0.9921136,0.0000143391,0.0002901285,0.0004006459],"study_design_scores_gemma":[0.0001609043,0.00002538869,0.003792878,0.00004308144,0.0000183073,0.000001620107,0.000003364405,0.001372733,0.9935647,0.0008164397,0.0001162741,0.00008431634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983211,0.0001827773,0.0004043175,0.00001777686,0.0004409641,0.0001911746,0.000002380368,0.000007256583,0.0004322685],"genre_scores_gemma":[0.9983699,0.00001645728,0.0002765631,0.000007183662,0.00002082657,0.0000159784,0.0000523879,0.00001087528,0.001229828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00248545,"threshold_uncertainty_score":0.3544505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412967913148053,"score_gpt":0.2572703159058554,"score_spread":0.2431406367743749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}