{"id":"W2587822335","doi":"10.1016/j.cmet.2017.01.009","title":"Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx","year":2017,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Boston Center For Blind Children; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; Institute of Genetics and Genomics of Geneva; Novo Nordisk Fonden; Agricultural Research Development Agency; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Howard Hughes Medical Institute; Juvenile Diabetes Research Foundation United States of America; European Commission; California Institute of Regenerative Medicine","keywords":"Biology; DNMT1; Cell; Cell biology; Islet; PAX4; Glucagon; Enteroendocrine cell; Cell type; Insulin; Endocrinology; Internal medicine; Homeobox; Gene; Gene expression; DNA methylation; Genetics; Medicine; Endocrine system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003479815,0.0004162768,0.0002833715,0.0002564625,0.0001525942,0.0006406601,0.0003412832,0.0003803177,0.003961375],"category_scores_gemma":[0.000147898,0.000300836,0.0003613823,0.0001641917,0.0002894626,0.0003745761,0.0003234442,0.001111748,0.0008390349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003542632,"about_ca_system_score_gemma":0.0003826979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007205176,"about_ca_topic_score_gemma":0.001353713,"domain_scores_codex":[0.9998109,0.00001825527,0.00001856761,0.00006534203,0.00004488626,0.00004205554],"domain_scores_gemma":[0.9998518,0.00001900916,0.00005860462,0.00002145524,0.00001219576,0.00003688893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001077924,0.00002832258,0.0002241737,0.00003166157,0.00001480843,0.00003119021,0.00002175803,0.00008743591,0.9952052,0.0003859789,0.00008343671,0.003778271],"study_design_scores_gemma":[0.00003756494,0.00020002,0.001172028,0.000007273341,0.00003888206,0.0001653176,0.00003367113,0.0005935995,0.9896025,0.0000741086,0.008070316,0.000004779522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670981,0.003062412,0.01918125,0.0006232574,0.0002870151,0.0001513282,0.001030926,0.0005472523,0.008018441],"genre_scores_gemma":[0.9702452,0.001526336,0.01079244,0.0001523077,0.00003794645,0.00006753986,0.0005838611,0.000125365,0.01646905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003961375,"threshold_uncertainty_score":0.01325214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006855614856371092,"score_gpt":0.2267510856850332,"score_spread":0.2198954708286621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}