{"id":"W2587842268","doi":"10.3390/ijms18020415","title":"Azacitidine for Front-Line Therapy of Patients with AML: Reproducible Efficacy Established by Direct Comparison of International Phase 3 Trial Data with Registry Data from the Austrian Azacitidine Registry of the AGMT Study Group","year":2017,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Celgene","keywords":"Azacitidine; Medicine; Front line; Clinical trial; Internal medicine; Oncology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["open_science"],"consensus_categories":[],"category_scores_codex":[0.002825462,0.0001878192,0.0005647416,0.0001368509,0.0001707643,0.0001743282,0.008047001,0.00005439225,0.00004243145],"category_scores_gemma":[0.00422638,0.00009413556,0.0001048614,0.0001825155,0.001152389,0.0007029255,0.0008359515,0.0003393029,1.861605e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000660613,"about_ca_system_score_gemma":0.0008288369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008040585,"about_ca_topic_score_gemma":0.0001051986,"domain_scores_codex":[0.9953318,0.0001816763,0.0009688334,0.000581758,0.002750801,0.0001851031],"domain_scores_gemma":[0.9923378,0.0004892472,0.002888765,0.002678129,0.001521733,0.0000843658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2506173,0.01968826,0.6060604,0.00004715932,0.0068612,0.0001195252,0.001255679,0.000427572,0.05698739,0.00009285654,0.02785978,0.02998294],"study_design_scores_gemma":[0.498088,0.03248128,0.2597505,0.002530147,0.001280006,0.0001046003,0.004610334,0.01170671,0.1674715,0.0001500862,0.02106601,0.0007608557],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903295,0.000366745,0.001928721,0.003360067,0.000567411,0.001071567,0.002135692,0.000003968856,0.0002363205],"genre_scores_gemma":[0.9965113,0.00008293451,0.002359488,0.00005172981,0.0003590764,0.000007152817,0.000561952,0.00001707238,0.00004932809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3463099,"threshold_uncertainty_score":0.9973199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1176557131447224,"score_gpt":0.4236414251960598,"score_spread":0.3059857120513374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}