{"id":"W2587842268","doi":"10.3390/ijms18020415","title":"Azacitidine for Front-Line Therapy of Patients with AML: Reproducible Efficacy Established by Direct Comparison of International Phase 3 Trial Data with Registry Data from the Austrian Azacitidine Registry of the AGMT Study Group","year":2017,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Celgene","keywords":"Azacitidine; Medicine; Front line; Clinical trial; Internal medicine; Oncology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03215034,0.0004117278,0.001075382,0.0009446326,0.0003238657,0.001461119,0.0006730843,0.0005488545,0.001303815],"category_scores_gemma":[0.02665729,0.0002513228,0.001242624,0.001318213,0.0006685447,0.0009639743,0.0009396752,0.001067954,0.0004082832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004037284,"about_ca_system_score_gemma":0.000759287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003343334,"about_ca_topic_score_gemma":0.0007512101,"domain_scores_codex":[0.9789026,0.01576002,0.001767761,0.001460407,0.001745303,0.0003639236],"domain_scores_gemma":[0.9756473,0.009656172,0.007535192,0.005359983,0.001274471,0.0005267537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2072087,0.002097588,0.6293944,0.001479342,0.01039803,0.000232518,0.001398806,0.003182796,0.01487008,0.0009660757,0.00357615,0.1251956],"study_design_scores_gemma":[0.02230413,0.03060565,0.9112321,0.0003043059,0.00663392,0.0009726632,0.0002840034,0.003238864,0.008854624,0.0008022233,0.01466017,0.0001074843],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842202,0.006273702,0.002052993,0.0002498115,0.00007553693,0.0005782141,0.002951114,0.00004084712,0.003557533],"genre_scores_gemma":[0.9908162,0.0007760627,0.00147081,0.0002017401,0.00007429452,0.0004156156,0.006007592,0.0000274639,0.0002100829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03215034,"threshold_uncertainty_score":0.1700293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1176557131447224,"score_gpt":0.4236414251960598,"score_spread":0.3059857120513374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}