{"id":"W2587843858","doi":"10.1016/j.bmc.2017.02.015","title":"Synthesis and biological evaluation of novel N3-substituted dihydropyrimidine derivatives as T-type calcium channel blockers and their efficacy as analgesics in mouse models of inflammatory pain","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Mibefradil; Chemistry; T-type calcium channel; Voltage-dependent calcium channel; Pharmacology; Calcium channel; Dihydropyridine; Pharmacophore; P-type calcium channel; Calcium; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009258452,0.0001725257,0.0002438744,0.00003809368,0.00008003558,0.0000092045,0.0001375909,0.0002565947,0.00002332335],"category_scores_gemma":[0.001970489,0.0001399754,0.00003618811,0.00006203837,0.0003975857,0.00001112468,0.0000942524,0.00008793124,2.295124e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002288211,"about_ca_system_score_gemma":0.0001380735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003896066,"about_ca_topic_score_gemma":0.000003203681,"domain_scores_codex":[0.9990057,0.000068968,0.0002899483,0.0003002316,0.0001960881,0.0001390516],"domain_scores_gemma":[0.999079,0.00005661809,0.0002682061,0.0002863839,0.0002226251,0.0000871183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000241068,0.00009763708,0.000809546,0.00007083722,0.00005009472,6.870399e-7,0.0001835923,0.0001026207,0.9974963,0.00001758614,0.00001702305,0.0009129731],"study_design_scores_gemma":[0.001226913,0.0001301174,0.004064653,0.00008826638,0.00003387077,0.00001174584,0.0005933064,0.01478342,0.9788209,0.0000799538,0.00002613272,0.0001407081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981792,0.0006883926,0.0005770829,0.0001890259,0.00005326323,0.0001648939,0.00001205689,0.000006951218,0.0001291307],"genre_scores_gemma":[0.9993916,0.0003067479,0.0000399445,0.00002625038,0.0001300249,0.000008747809,0.00005529127,0.00001255107,0.00002886805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01867543,"threshold_uncertainty_score":0.570803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06082186546480767,"score_gpt":0.291805972724721,"score_spread":0.2309841072599133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}