{"id":"W2587881875","doi":"10.1182/blood.v126.23.5351.5351","title":"Targeting Cancer Stem Cell Survival in Plasma Cell Leukemia with a Pan-BCL2 Inhibitor","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Plasma cell leukemia; Stem cell; Cancer research; Myeloid leukemia; Leukemia; Multiple myeloma; Plasma cell; Biology; Cancer stem cell; Bone marrow; CD34; Molecular biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009231641,0.0002400924,0.0002178238,0.000235015,0.0001008533,0.0002325161,0.0001747132,0.0001801757,0.001805083],"category_scores_gemma":[0.00006335178,0.00006754714,0.0001320648,0.0001927936,0.0001236319,0.0001475593,0.0001234658,0.0004952734,0.0002605536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002507561,"about_ca_system_score_gemma":0.0001842803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003118383,"about_ca_topic_score_gemma":0.0007306155,"domain_scores_codex":[0.9999417,0.000007767788,0.000004425261,0.00001240092,0.00001929283,0.00001438154],"domain_scores_gemma":[0.999971,0.000004827532,0.000006284669,0.000004339183,0.000005383355,0.000008132958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005155078,0.0002073814,0.0005363853,0.0001447097,0.0000236718,0.0000544201,0.00002638374,0.0003437103,0.9796395,0.0002936314,0.0005059918,0.01770864],"study_design_scores_gemma":[0.0001868094,0.001594978,0.003931018,0.00001532937,0.00005019217,0.0004479764,0.0000348111,0.00252251,0.9775668,0.0001235018,0.01352073,0.000005406959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876418,0.005170982,0.003715447,0.000174435,0.00005154665,0.0000858217,0.0004637841,0.0002419052,0.002454262],"genre_scores_gemma":[0.9933303,0.001638903,0.001768835,0.00008817294,0.00001021699,0.00007511081,0.0006022158,0.00001094953,0.002475278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001805083,"threshold_uncertainty_score":0.006038666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02967280122887441,"score_gpt":0.2736138966412132,"score_spread":0.2439410954123388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}