{"id":"W2587908412","doi":"10.1093/neuonc/now212.317","title":"GENT-11. SMALL MOLECULE EPIGENETIC SCREEN IDENTIFIES NOVEL EZH2 AND HDAC INHIBITORS THAT TARGET GLIOBLASTOMA BRAIN TUMOR-INITIATING CELLS","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of Calgary; Hospital for Sick Children","funders":"","keywords":"Epigenetics; In vivo; Cancer research; Biology; In vitro; EZH2; Cytotoxicity; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004182325,0.0003313619,0.0003362373,0.0001328678,0.0001719893,0.00005365289,0.0002613496,0.0003160435,0.0000426927],"category_scores_gemma":[0.0003881952,0.0002868158,0.0001274739,0.0001138262,0.0002369571,0.0000118257,0.0003784873,0.0001412978,0.0000249104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004193769,"about_ca_system_score_gemma":0.0001496091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004108038,"about_ca_topic_score_gemma":0.0002885495,"domain_scores_codex":[0.9977253,0.0002753922,0.0004579723,0.0007904081,0.0001997438,0.0005511964],"domain_scores_gemma":[0.9986374,0.0002721682,0.0003058862,0.0004294761,0.0001254869,0.0002295273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007913212,0.00008474087,0.004416554,0.00001835746,0.000029312,0.00003238541,0.00007459399,0.00003086944,0.9884965,0.00003170849,0.0006864087,0.006019406],"study_design_scores_gemma":[0.001264979,0.001122948,0.002160984,0.00002043315,0.00002908268,0.00003073458,0.00007285582,0.00006530403,0.9381847,0.0001464743,0.0565712,0.0003303001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869759,0.001016112,0.009044848,0.001189699,0.0006098567,0.0003660017,0.00007861821,0.00003558256,0.0006833567],"genre_scores_gemma":[0.9953256,0.0003779946,0.002305327,0.001207192,0.0004822452,0.00004059258,0.00003324246,0.0000743349,0.0001534649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05588479,"threshold_uncertainty_score":0.9999584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.017561237278052,"score_gpt":0.2555079050579245,"score_spread":0.2379466677798725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}