{"id":"W2587908412","doi":"10.1093/neuonc/now212.317","title":"GENT-11. SMALL MOLECULE EPIGENETIC SCREEN IDENTIFIES NOVEL EZH2 AND HDAC INHIBITORS THAT TARGET GLIOBLASTOMA BRAIN TUMOR-INITIATING CELLS","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of Calgary; Hospital for Sick Children","funders":"","keywords":"Epigenetics; In vivo; Cancer research; Biology; In vitro; EZH2; Cytotoxicity; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001930357,0.0006372152,0.0007712116,0.0006310281,0.0001715156,0.0002960677,0.0003593872,0.0003428905,0.002580631],"category_scores_gemma":[0.0001378179,0.0002243208,0.0003683308,0.0004127171,0.0001619419,0.0001428916,0.0002505508,0.0004424673,0.0005761753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000461687,"about_ca_system_score_gemma":0.0005096187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001565052,"about_ca_topic_score_gemma":0.009386593,"domain_scores_codex":[0.9998592,0.00002054004,0.00001099941,0.00002771725,0.00004695326,0.00003458328],"domain_scores_gemma":[0.999944,0.00001061013,0.000009220083,0.000005614037,0.00001041033,0.0000202876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004904248,0.0002851573,0.001292751,0.0001183876,0.00005893438,0.0001381625,0.00001623112,0.0007150514,0.9780126,0.0001622428,0.0004730839,0.01823702],"study_design_scores_gemma":[0.0002619694,0.003827075,0.008721344,0.00001040921,0.0001846452,0.0005765705,0.00002429831,0.00180494,0.9771642,0.00005460815,0.007355408,0.00001449545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762491,0.00528198,0.004871553,0.0002931872,0.00006035859,0.0004428724,0.003851181,0.0005181798,0.008431462],"genre_scores_gemma":[0.9728971,0.004378439,0.008032736,0.0002509286,0.00002048569,0.000181275,0.007339649,0.00005716694,0.006842199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002580631,"threshold_uncertainty_score":0.008633137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.017561237278052,"score_gpt":0.2555079050579245,"score_spread":0.2379466677798725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}