{"id":"W2587925217","doi":"10.1093/neuonc/now212.893","title":"TMOD-23. DEVELOPMENT AND APPLICATION OF A NOVEL MODEL OF HUMAN LUNG-TO- BRAIN METASTASIS TO IDENTIFY GENETIC REGULATORS OF BRAIN METASTASIS INITIATING CELLS","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph's Hospital; Hospital for Sick Children; Occupational Cancer Research Centre; Princess Margaret Cancer Centre; University of Toronto; McMaster University","funders":"","keywords":"Brain metastasis; Metastasis; Biology; Cancer research; Cancer; Gene knockdown; Lung cancer; Cancer stem cell; Pathology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004224374,0.0005706792,0.0003703518,0.000603714,0.0003614553,0.0006183844,0.0007119539,0.000583107,0.003554729],"category_scores_gemma":[0.000160489,0.0002907485,0.0005813033,0.0003322728,0.0004209605,0.0002858249,0.0003872186,0.001366627,0.001042724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006478658,"about_ca_system_score_gemma":0.0007471951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002152543,"about_ca_topic_score_gemma":0.002664534,"domain_scores_codex":[0.9995906,0.00004614142,0.00004106976,0.0001192416,0.0001297104,0.00007318929],"domain_scores_gemma":[0.9998468,0.00002133286,0.00003462985,0.00002284018,0.00001730032,0.00005700568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002306863,0.0001367315,0.0001960759,0.00007831672,0.0000131029,0.0001545059,0.00002743489,0.0004743949,0.9933036,0.0008972978,0.0003588007,0.00412895],"study_design_scores_gemma":[0.0001165055,0.001278583,0.00177946,0.00001699553,0.00003366946,0.0007251477,0.00003734515,0.002732705,0.9664083,0.0002521847,0.026605,0.00001409922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8639909,0.008053994,0.08559748,0.001582519,0.0007581813,0.00200694,0.01525493,0.001446368,0.02130873],"genre_scores_gemma":[0.915495,0.004767777,0.04005992,0.0005227784,0.00005315042,0.002006704,0.008949286,0.0002466371,0.02789875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003554729,"threshold_uncertainty_score":0.01189178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02283054752021342,"score_gpt":0.3167498356188324,"score_spread":0.293919288098619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}