{"id":"W2587925217","doi":"10.1093/neuonc/now212.893","title":"TMOD-23. DEVELOPMENT AND APPLICATION OF A NOVEL MODEL OF HUMAN LUNG-TO- BRAIN METASTASIS TO IDENTIFY GENETIC REGULATORS OF BRAIN METASTASIS INITIATING CELLS","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph's Hospital; Hospital for Sick Children; Occupational Cancer Research Centre; Princess Margaret Cancer Centre; University of Toronto; McMaster University","funders":"","keywords":"Brain metastasis; Metastasis; Biology; Cancer research; Cancer; Gene knockdown; Lung cancer; Cancer stem cell; Pathology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004157953,0.0001956495,0.0004189944,0.0002193561,0.00004907701,0.000004362778,0.000209163,0.0002080253,0.00000558578],"category_scores_gemma":[0.0001867525,0.0001846047,0.00008694598,0.0002473689,0.0001159539,0.000007848739,0.0002444958,0.0000562287,0.00000149579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008196443,"about_ca_system_score_gemma":0.0002368978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002380794,"about_ca_topic_score_gemma":0.0001120757,"domain_scores_codex":[0.9981624,0.0001309284,0.0007427659,0.000515214,0.0002093623,0.0002392694],"domain_scores_gemma":[0.9986131,0.0001172228,0.000493045,0.000426048,0.0002253978,0.0001252238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009831234,0.0001112367,0.000248377,0.00006764819,0.000109738,3.291533e-7,0.0003132462,0.005950783,0.948562,0.000115188,0.0004675997,0.04395556],"study_design_scores_gemma":[0.0009998141,0.0005600183,0.002273869,0.00002790178,0.00008255259,0.000007479708,0.00003655809,0.001415463,0.991972,0.00005379532,0.002398661,0.0001718613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.864803,0.000101076,0.1337124,0.0006509901,0.00005727676,0.0005398961,0.00007788222,0.000007557003,0.00004999715],"genre_scores_gemma":[0.9757441,0.00001616977,0.02373006,0.0002865658,0.00004138224,0.0000848144,0.00002929122,0.00003632896,0.00003131842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1109411,"threshold_uncertainty_score":0.752796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02283054752021342,"score_gpt":0.3167498356188324,"score_spread":0.293919288098619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}