{"id":"W2587948547","doi":"10.1093/neuonc/nox083.164","title":"MEDU-13. CONVERGENCE OF BMI1 AND CHD7 ON ERK SIGNALLING IN MEDULLOBLASTOMA","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"BMI1; Medulloblastoma; Biology; Cancer research; Carcinogenesis; Polycomb-group proteins; Neural stem cell; Gene silencing; Stem cell; Cell biology; Cancer; Genetics; Repressor; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009031888,0.0002757412,0.0002035979,0.0004672653,0.0002762553,0.000395261,0.0002281708,0.000281912,0.003240441],"category_scores_gemma":[0.0001296125,0.0001573612,0.0002976734,0.0001763844,0.0002106538,0.0001833369,0.0004416849,0.0003861996,0.0009272035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007437961,"about_ca_system_score_gemma":0.0003206983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001791909,"about_ca_topic_score_gemma":0.004137081,"domain_scores_codex":[0.9998765,0.00001256594,0.000006171605,0.00001877548,0.00004871196,0.00003715935],"domain_scores_gemma":[0.9999205,0.000006842155,0.00001779005,0.000004170504,0.00001256172,0.00003820155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006172787,0.00003196633,0.003383936,0.0001673629,0.00001752053,0.0003931297,0.00003073749,0.0001896369,0.9868491,0.0006956688,0.0003860016,0.007237665],"study_design_scores_gemma":[0.0000883886,0.0003798542,0.160993,0.00004883359,0.00005862143,0.002413651,0.0002005041,0.003087177,0.8101209,0.0006962002,0.02188925,0.00002366623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976361,0.007098788,0.002011881,0.0004397497,0.00009330727,0.00004135394,0.001598868,0.0002454959,0.01210953],"genre_scores_gemma":[0.9895418,0.001474881,0.001099834,0.00009777761,0.00001300234,0.00002372305,0.001496117,0.00002651045,0.006226245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003240441,"threshold_uncertainty_score":0.01084036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02329733139993394,"score_gpt":0.3142940085486856,"score_spread":0.2909966771487517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}