{"id":"W2587966486","doi":"10.1093/annonc/mdw372.54","title":"TITAN: A randomized, double-blind, placebo-controlled, phase 3 trial of apalutamide (ARN-509) plus androgen deprivation therapy (ADT) in metastatic hormone-sensitive prostate cancer (mHSPC)","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Androgen deprivation therapy; Placebo; Prostate cancer; Oncology; Internal medicine; Antiandrogen; Double blind; Urology; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001259649,0.002222509,0.00308147,0.0006500076,0.0006068057,0.001104598,0.001466956,0.001681616,0.01057801],"category_scores_gemma":[0.001447713,0.0008474741,0.001623181,0.0004866424,0.001712154,0.001441164,0.0004523768,0.003690526,0.001552922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008077252,"about_ca_system_score_gemma":0.001722034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00177893,"about_ca_topic_score_gemma":0.005345864,"domain_scores_codex":[0.9995739,0.0001992914,0.00002135848,0.00008531399,0.00003541102,0.00008479276],"domain_scores_gemma":[0.999437,0.0001330744,0.0001048545,0.00004885912,0.00003287079,0.0002433209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9826009,0.004634643,0.0001581641,0.0004964959,0.0005107914,0.00002449005,0.00003742508,0.0002445473,0.00233983,0.0001646435,0.001001172,0.007786998],"study_design_scores_gemma":[0.9759322,0.02270158,0.0004090093,0.00001066118,0.0001357442,0.00001470785,0.00001238295,0.0001954765,0.0001791839,0.00009144143,0.0003084233,0.000009219223],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764548,0.004442898,0.001458716,0.001236617,0.001247881,0.007505779,0.00260863,0.0007182783,0.004326442],"genre_scores_gemma":[0.9702363,0.00344236,0.00304198,0.001979727,0.0005865346,0.009527349,0.002455511,0.0001157549,0.008614456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01057801,"threshold_uncertainty_score":0.03538698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1325500462624811,"score_gpt":0.4467599327664725,"score_spread":0.3142098865039914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}