{"id":"W2588002066","doi":"10.1182/blood.v118.21.83.83","title":"Late Relapses Following All-Trans Retinoic Acid for Acute Promyelocytic Leukemia Are Uncommon, Respond Well to Salvage Therapy and Occur Independently of Prognostic Factors At Diagnosis: Long-Term Follow-up of North American Intergroup Study I0129","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Medicine; Acute promyelocytic leukemia; Chemotherapy; Internal medicine; Anthracycline; Chemotherapy regimen; Arsenic trioxide; Surgery; Cumulative incidence; Salvage therapy; Induction chemotherapy; Randomized controlled trial; Oncology; Gastroenterology; Retinoic acid; Cohort; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002255272,0.0003889847,0.0005844978,0.0001169361,0.00009204138,0.00002082225,0.0004866419,0.0001318358,0.000006235935],"category_scores_gemma":[0.0001458862,0.0003351445,0.0002456654,0.0002395245,0.0001453352,0.00001711828,0.0002247164,0.0001429192,9.905488e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003864889,"about_ca_system_score_gemma":0.0001203372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005760389,"about_ca_topic_score_gemma":0.0007783957,"domain_scores_codex":[0.9979729,0.0001332807,0.0005700541,0.0006551539,0.0002641908,0.0004044428],"domain_scores_gemma":[0.9986647,0.00006970749,0.0004250046,0.0005446558,0.000138698,0.0001572668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001081251,0.0005479307,0.881685,0.000149244,0.001233456,0.00003979907,0.002091426,0.00000168219,0.1125712,4.406673e-7,0.00003143257,0.0005671584],"study_design_scores_gemma":[0.002734317,0.003354453,0.4672079,0.00007943508,0.0005381573,0.000006207674,0.0002833163,6.187946e-7,0.5255016,0.00000340272,0.00003588607,0.0002546683],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970847,0.0009784246,0.0001185033,0.000009054156,0.000131463,0.001540733,0.00008245171,0.00002405756,0.00003060772],"genre_scores_gemma":[0.9985402,0.0004611505,0.0002672728,0.00004863778,0.0000401119,0.0003305617,0.000110936,0.00006846571,0.0001326174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4144771,"threshold_uncertainty_score":0.9999101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02131233401937273,"score_gpt":0.2624086929589308,"score_spread":0.241096358939558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}