{"id":"W2588053926","doi":"10.1016/j.pharmthera.2017.02.029","title":"Myotoxicity of statins: Mechanism of action","year":2017,"lang":"en","type":"review","venue":"Pharmacology & Therapeutics","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":160,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Pharmacology; Statin; Chemistry; Internal medicine; Myocyte; Endocrinology; Atorvastatin; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007503545,0.000299497,0.002545888,0.0001715551,0.00007333732,0.000003742447,0.0002493035,0.0004261671,0.0001549099],"category_scores_gemma":[0.000007732273,0.000232727,0.0009693609,0.0001062022,0.0001637519,0.00003638721,0.00006595276,0.0005639882,0.00001203728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001137288,"about_ca_system_score_gemma":0.0008538077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004385153,"about_ca_topic_score_gemma":0.000002501331,"domain_scores_codex":[0.9980472,0.0003523612,0.0007169478,0.0002785926,0.0003446451,0.0002601991],"domain_scores_gemma":[0.9978552,0.00008252469,0.001101599,0.0006656873,0.0002008145,0.00009421692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005466087,0.0002207598,0.000001391015,0.02673023,0.004418581,0.00001310743,0.0000548544,1.162583e-7,0.0007066523,0.0001181159,0.00006351093,0.967618],"study_design_scores_gemma":[0.00119118,0.0003732732,0.000005184009,0.002034218,0.01679594,0.00008395206,0.0000136209,0.000009367448,0.005637808,0.00008879741,0.973613,0.000153716],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002136538,0.9963268,0.0003233248,0.00006608811,0.00084126,0.001719687,0.00007787464,0.0000265367,0.0004047956],"genre_scores_gemma":[0.0007775462,0.9977823,0.0002709513,0.0003944568,0.0004025338,0.00009960627,0.00004026307,0.0000569218,0.0001754492],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9735494,"threshold_uncertainty_score":0.9490331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3143587471228095,"score_gpt":0.4997394761489723,"score_spread":0.1853807290261628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}