{"id":"W2588061824","doi":"10.1038/ncomms14278","title":"Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Ottawa Hospital Research Institute; Fondation Brain Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; University of Ottawa","keywords":"Cytotoxic T cell; Immune system; Immune checkpoint; Cancer research; Innate immune system; Apoptosis; Cancer; Immunology; Cancer cell; CD8; Biology; Immunotherapy; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001301545,0.000260567,0.0002873369,0.0004925338,0.00008432653,0.0002051985,0.000138784,0.0001929238,0.0007676441],"category_scores_gemma":[0.00008393135,0.0000984634,0.000156895,0.0002164745,0.0001106796,0.0001467778,0.0001585975,0.0003110598,0.0002240852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001749744,"about_ca_system_score_gemma":0.0002162354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001664474,"about_ca_topic_score_gemma":0.0007286741,"domain_scores_codex":[0.9999255,0.00001493916,0.000006563461,0.000008326415,0.00001918045,0.00002549718],"domain_scores_gemma":[0.9999555,0.000006924998,0.00001112598,0.000004653868,0.000004434142,0.00001742413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001121235,0.0005062685,0.0006392234,0.0001392918,0.0000443877,0.0001456409,0.0000234173,0.001091651,0.9581858,0.0005711516,0.0005356847,0.03699628],"study_design_scores_gemma":[0.0004729537,0.007315564,0.005108977,0.00001881926,0.0001109876,0.0005307461,0.00002132743,0.002536055,0.9715679,0.0002455893,0.01206096,0.00001008787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899645,0.004228489,0.001528755,0.0001426705,0.00007638333,0.0001174706,0.0001538001,0.0001204019,0.003667662],"genre_scores_gemma":[0.9950465,0.002009532,0.001454169,0.00008015745,0.00004250206,0.00005499456,0.0001667553,0.00001264505,0.001132852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007676441,"threshold_uncertainty_score":0.002568066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01617161382841478,"score_gpt":0.3029597928864098,"score_spread":0.286788179057995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}