{"id":"W2588091899","doi":"10.1093/annonc/mdw368.45","title":"Retrospective review of new phase I clinic referrals and enrolment in the molecular screening era","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Demographics; Clinical trial; Profiling (computer programming); Internal medicine; Retrospective cohort study; Molecular diagnostics; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001382882,0.0002153047,0.000601879,0.002448553,0.001035636,0.001243425,0.0008539488,0.0007563035,0.004609152],"category_scores_gemma":[0.007056217,0.0004918808,0.0005311597,0.004046682,0.0005581447,0.0006987589,0.0007177569,0.0006367705,0.0008098759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001360309,"about_ca_system_score_gemma":0.001760026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01396154,"about_ca_topic_score_gemma":0.014226,"domain_scores_codex":[0.9967889,0.0006092834,0.0004106383,0.001012598,0.0005825423,0.0005961839],"domain_scores_gemma":[0.9898281,0.002364722,0.004256879,0.0006266268,0.001420893,0.001502779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00031462,0.00007702863,0.9941115,0.0000793125,0.00004780468,0.001012339,0.000296312,0.00002374196,0.0004692207,0.00006684141,0.001138392,0.002362953],"study_design_scores_gemma":[0.00001931326,0.0001559266,0.9938446,0.00007014851,0.00006439756,0.002369124,0.001099636,0.00007371917,0.0001407933,0.00002974249,0.002122023,0.00001052934],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912185,0.001702158,0.0001916112,0.0002051039,0.00002824837,0.0001315165,0.00419264,0.00001656724,0.00231367],"genre_scores_gemma":[0.9951112,0.0006673819,0.0001843935,0.000432917,0.00004323453,0.0001079029,0.002855203,0.00001941865,0.0005784617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01396154,"threshold_uncertainty_score":0.02776057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08229589332991764,"score_gpt":0.4211231559248956,"score_spread":0.3388272625949779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}