{"id":"W2588106160","doi":"10.1093/annonc/mdw378.16","title":"Updated results from a phase I study of nivolumab (Nivo) in combination with ipilimumab (Ipi) in metastatic renal cell carcinoma (mRCC): The CheckMate 016 study","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; BC Cancer Agency; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Nivolumab; Ipilimumab; Internal medicine; Tolerability; Renal cell carcinoma; Adverse effect; Sunitinib; Oncology; Toxicity; Gastroenterology; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0050296,0.0009421787,0.002496065,0.0005127423,0.000298123,0.00205413,0.001055313,0.0009300187,0.004493176],"category_scores_gemma":[0.006811237,0.0005227196,0.003377128,0.001147605,0.0003457821,0.001178133,0.0005549632,0.001982244,0.0009233103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001145072,"about_ca_system_score_gemma":0.001228488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002041008,"about_ca_topic_score_gemma":0.005745006,"domain_scores_codex":[0.9986304,0.0006282795,0.0001399642,0.0001966218,0.0002708339,0.0001338483],"domain_scores_gemma":[0.9957101,0.001587815,0.001243521,0.0004391552,0.0005443738,0.0004750633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.444095,0.002755421,0.06300335,0.01004464,0.0413156,0.0003970447,0.0003281185,0.005066816,0.01356829,0.0007480229,0.08123096,0.3374468],"study_design_scores_gemma":[0.352861,0.0575802,0.3290751,0.00179665,0.1084512,0.001706366,0.0002681447,0.002213324,0.006199358,0.001831415,0.1377213,0.0002958647],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7298027,0.1504584,0.003113755,0.005913245,0.002565799,0.00231153,0.08380365,0.0004804856,0.02155038],"genre_scores_gemma":[0.8667957,0.03008892,0.005663065,0.006691983,0.001253013,0.001669436,0.08112032,0.0002439802,0.006473631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0050296,"threshold_uncertainty_score":0.02659941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06595504791265101,"score_gpt":0.3686164213189909,"score_spread":0.3026613734063399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}