{"id":"W2588154290","doi":"10.1016/j.bmc.2017.02.016","title":"Synthesis and activity of nucleoside-based antiprotozoan compounds","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nucleoside; Chemistry; Adenosine deaminase; Nucleotide salvage; Purine metabolism; Guanosine; Adenosine; Nucleotide; IC50; Stereochemistry; Purine; Purine nucleoside phosphorylase; Plasmodium falciparum; Biochemistry; Antiprotozoal; In vitro; Enzyme; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004327088,0.0002079482,0.0005859174,0.00003993093,0.0003015426,0.00003357044,0.0002890849,0.0001337858,0.0002687226],"category_scores_gemma":[0.002393165,0.0001699137,0.00008483484,0.00006768559,0.00105572,0.0000767596,0.0001822096,0.0002966893,0.000007398042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008205178,"about_ca_system_score_gemma":0.000248886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001850077,"about_ca_topic_score_gemma":0.000005742042,"domain_scores_codex":[0.9984573,0.00002504132,0.0002418124,0.0003609608,0.0006000405,0.0003148965],"domain_scores_gemma":[0.9982073,0.0002024552,0.0002559872,0.0008892737,0.0001810143,0.0002640082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003088634,0.0001769883,0.08377492,0.001069303,0.0001140102,0.00007244938,0.00004180308,1.088086e-8,0.9080715,0.000003359296,0.0009982017,0.005368617],"study_design_scores_gemma":[0.001068905,0.0001001955,0.2599509,0.0004378185,0.0001129746,0.00006251015,0.0000942898,0.00004577553,0.7373744,0.000009990025,0.0006362442,0.0001059549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984318,0.0003689626,0.00002635412,0.00504586,0.00003952973,0.0003049799,0.00001438636,0.00004338976,0.009838593],"genre_scores_gemma":[0.9990479,0.0001440267,0.0001875336,0.00007067475,0.0002111541,0.00002772521,0.00000245545,0.00002851725,0.0002799594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.176176,"threshold_uncertainty_score":0.6928881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03668549274770019,"score_gpt":0.3150172013420203,"score_spread":0.2783317085943202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}