{"id":"W2588188834","doi":"10.1016/j.chembiol.2017.02.004","title":"Stimulating Central Carbon Metabolism to Re-sensitize Pseudomonas aeruginosa to Aminoglycosides","year":2017,"lang":"en","type":"letter","venue":"Cell chemical biology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Pseudomonas aeruginosa; Potentiator; Tobramycin; Microbiology; Aminoglycoside; Bacteria; Multidrug tolerance; Antibiotics; Biology; Genetics; Biofilm","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009873747,0.0004555215,0.0004623417,0.0001706873,0.0006911407,0.001039164,0.0005697235,0.007589712,0.004712155],"category_scores_gemma":[0.003152158,0.0001955037,0.0005562452,0.0001210292,0.00124349,0.0005415912,0.0007476599,0.008501651,0.002344933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001306679,"about_ca_system_score_gemma":0.000884038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006533707,"about_ca_topic_score_gemma":0.001394516,"domain_scores_codex":[0.9995005,0.00009823842,0.00003688384,0.00004442206,0.000200283,0.0001196414],"domain_scores_gemma":[0.9989597,0.0005778354,0.00006495297,0.00008549949,0.0001564499,0.0001556667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001681702,0.0008313953,0.002547167,0.0002892862,0.00007168691,0.01086805,0.0002917506,0.0005360376,0.07182521,0.01599781,0.7690173,0.1260426],"study_design_scores_gemma":[0.001400827,0.001300013,0.002622997,0.0001737037,0.00009333316,0.006039896,0.000399109,0.00252834,0.08487544,0.02199758,0.8784814,0.00008734289],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.04780022,0.009568069,0.002196372,0.8706935,0.03907286,0.0001923368,0.0001595179,0.0003953306,0.02992164],"genre_scores_gemma":[0.3231601,0.01342122,0.003932092,0.5390853,0.04159316,0.0004738526,0.0002418022,0.0001629846,0.0779296],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.007589712,"threshold_uncertainty_score":0.01576376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242704060229698,"score_gpt":0.2403950601249645,"score_spread":0.2279680195226675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}