{"id":"W2588218255","doi":"10.1093/neuonc/now212.478","title":"MPTH-41. MGMT STATUS PREDICTS SURVIVAL OUTCOMES IN NRG ONCOLOGY/RTOG 0424: A PHASE II TRIAL OF TEMOZOLOMIDE-BASED CHEMORADIOTHERAPY FOR HIGH RISK LOW-GRADE GLIOMAS","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame; Princess Margaret Cancer Centre; University Health Network; London Health Sciences Centre; Western University","funders":"","keywords":"Temozolomide; Oncology; Glioma; Internal medicine; Medicine; Chemoradiotherapy; Hazard ratio; Methyltransferase; Methylation; Proportional hazards model; Biomarker; Radiation therapy; Oligodendroglioma; O-6-methylguanine-DNA methyltransferase; Astrocytoma; Cancer research; Biology; Confidence interval; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0014717,0.0008025209,0.0009766374,0.000302141,0.0001382891,0.000609854,0.0005195658,0.0004585827,0.0014745],"category_scores_gemma":[0.0009244278,0.0002852918,0.0006988325,0.0002930989,0.0003213808,0.000267801,0.0002725818,0.0009813309,0.0004255106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005732395,"about_ca_system_score_gemma":0.0008106952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008452354,"about_ca_topic_score_gemma":0.002571525,"domain_scores_codex":[0.9995859,0.0002665092,0.00001300303,0.0000456264,0.00004166988,0.00004725105],"domain_scores_gemma":[0.9996023,0.00006013887,0.0001421544,0.00003136996,0.00001735243,0.0001467054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5594775,0.02115772,0.1492701,0.0007154801,0.002736066,0.0002650977,0.0002754766,0.006066599,0.05934728,0.0001411367,0.003848374,0.1966992],"study_design_scores_gemma":[0.1348888,0.4180544,0.4120553,0.00007151961,0.002590636,0.0007573874,0.0001543448,0.009092611,0.01358045,0.000383637,0.008284358,0.00008635818],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985105,0.0007514465,0.00007934275,0.00009196199,0.0000144372,0.0001102567,0.0002097118,0.00002061789,0.0002117169],"genre_scores_gemma":[0.9966402,0.0005016372,0.0005177,0.0001300774,0.00004007515,0.0002518684,0.0007682954,0.00001433787,0.00113582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0014745,"threshold_uncertainty_score":0.007783175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03660164644227795,"score_gpt":0.3806421536693743,"score_spread":0.3440405072270963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}