{"id":"W2588264326","doi":"10.1093/ndt/gfw157.32","title":"SP071APABETALONE (RVX-208), A SELECTIVE BROMODOMAIN AND EXTRA-TERMINAL (BET) PROTEIN INHIBITOR, DECREASES ABUNDANCE AND ACTIVITY OF COMPLEMENT PROTEINS IN VITRO, IN MICE AND IN CLINICAL STUDIES","year":2016,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Bromodomain; Medicine; In vitro; Complement (music); BET inhibitor; Pharmacology; Terminal (telecommunication); Biochemistry; Epigenetics; Biology; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001704586,0.0004447116,0.0003439947,0.0002482725,0.00007190386,0.0001688428,0.0001959428,0.0002089068,0.002421806],"category_scores_gemma":[0.00009051072,0.0001223691,0.0001860236,0.0000959118,0.0002168221,0.0001221755,0.00008163422,0.00054999,0.000536486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000163431,"about_ca_system_score_gemma":0.0001898468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001998815,"about_ca_topic_score_gemma":0.0004724483,"domain_scores_codex":[0.9999136,0.00001867627,0.00000598133,0.00001491501,0.00002527589,0.0000216272],"domain_scores_gemma":[0.9999268,0.0000106678,0.0000231469,0.000004967888,0.000007323203,0.00002718296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001770387,0.000296109,0.0003615419,0.0001144581,0.00002700144,0.00004069723,0.000006215083,0.00008218535,0.9863203,0.00003959153,0.0002807552,0.0106606],"study_design_scores_gemma":[0.0008471614,0.01431683,0.008336878,0.00001815736,0.00007588913,0.0007071552,0.00001771529,0.000624644,0.9709185,0.00004062533,0.004087512,0.000008861858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893816,0.005869591,0.001698325,0.0002351793,0.00007947984,0.00005307006,0.0005510795,0.0002635358,0.001868063],"genre_scores_gemma":[0.9894068,0.003441687,0.001521213,0.0001289914,0.0000421775,0.00008702643,0.0009386454,0.0000344117,0.004399094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002421806,"threshold_uncertainty_score":0.008101702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01789933179938176,"score_gpt":0.2936385203466182,"score_spread":0.2757391885472365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}