{"id":"W2588365713","doi":"10.1097/mol.0000000000000386","title":"Complexity of mechanisms among human proprotein convertase subtilisin–kexin type 9 variants","year":2017,"lang":"en","type":"review","venue":"Current Opinion in Lipidology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Robarts Clinical Trials","funders":"","keywords":"PCSK9; Kexin; Proprotein convertase; Mendelian randomization; Subtilisin; Biology; Cholesterol; Loss function; Disease; LDL receptor; Internal medicine; Bioinformatics; Genetics; Endocrinology; Medicine; Lipoprotein; Gene; Phenotype; Biochemistry; Genetic variants; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008302788,0.0007192971,0.001674123,0.001917978,0.0001829912,0.0009451683,0.0008335174,0.001050398,0.002685913],"category_scores_gemma":[0.002146162,0.0002222688,0.000717867,0.00178113,0.0003925865,0.001061188,0.0006724653,0.001071526,0.0007091472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004546907,"about_ca_system_score_gemma":0.001593726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000834784,"about_ca_topic_score_gemma":0.0008553377,"domain_scores_codex":[0.9996704,0.0000650494,0.00008842721,0.00006719909,0.00008620827,0.00002273336],"domain_scores_gemma":[0.99891,0.0006479887,0.0002227298,0.00001984258,0.0001580231,0.00004153518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000173492,0.00003028718,0.000627958,0.06550678,0.0004985725,0.000417671,0.0001021403,0.0003444054,0.001147432,0.003102422,0.02762672,0.9004221],"study_design_scores_gemma":[0.00005601431,0.0001775796,0.004280282,0.02986228,0.001325116,0.005382782,0.0001759961,0.0001382801,0.0007841232,0.003815237,0.9539468,0.00005550716],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009364334,0.9992078,0.00006324916,0.0002921039,0.0001316694,0.000002555002,0.00001780714,0.000003146238,0.0001880413],"genre_scores_gemma":[0.0006765904,0.9987015,0.00007690372,0.0002045434,0.0001782748,0.000004643947,0.00003150955,0.000001057438,0.000124973],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002685913,"threshold_uncertainty_score":0.008985221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3845486806153595,"score_gpt":0.4699951825021644,"score_spread":0.08544650188680497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}