{"id":"W2588366326","doi":"10.1038/tp.2016.291","title":"Rare damaging variants in DNA repair and cell cycle pathways are associated with hippocampal and cognitive dysfunction: a combined genetic imaging study in first-episode treatment-naive patients with schizophrenia","year":2017,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Natural Science Foundation of China","keywords":"Hippocampus; Schizophrenia (object-oriented programming); Hippocampal formation; Neuroscience; Dentate gyrus; Cognition; Brain Structure and Function; Psychology; Functional magnetic resonance imaging; Medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001912634,0.0004598745,0.000485311,0.001055256,0.0005126526,0.0003725463,0.0002521283,0.0004715102,0.001341608],"category_scores_gemma":[0.0009126085,0.0002707609,0.0003930848,0.0005567038,0.0002854861,0.000205298,0.0003522982,0.0003084757,0.0001249013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002891799,"about_ca_system_score_gemma":0.0001964691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005032237,"about_ca_topic_score_gemma":0.00761408,"domain_scores_codex":[0.9997788,0.00003551129,0.00003584367,0.00008528609,0.00003711821,0.00002752319],"domain_scores_gemma":[0.9995596,0.00008220041,0.0002087871,0.00003613996,0.0000327544,0.00008058515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007701438,0.0001152057,0.9781431,0.00003599248,0.0002553309,0.001514162,0.0004551067,0.0001020706,0.01522606,0.00002786859,0.00005604716,0.003298842],"study_design_scores_gemma":[0.00001485925,0.0001355166,0.9974476,0.000004436641,0.00006153857,0.001708278,0.0001231432,0.0001273129,0.0003056768,0.00001715733,0.00004941091,0.000005041931],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997947,0.00007038344,0.0000322678,0.000006903846,8.429034e-7,0.000002676954,0.00004477835,0.000001441933,0.00004608606],"genre_scores_gemma":[0.9997813,0.0000360522,0.00004769796,0.000007900156,0.000001691654,0.000002693356,0.00007767316,0.000001260052,0.00004377369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005032237,"threshold_uncertainty_score":0.01000589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009039537051780979,"score_gpt":0.2265067339957923,"score_spread":0.2174671969440113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}