{"id":"W2588377216","doi":"10.1073/pnas.1700453114","title":"Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET","year":2017,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; American Heart Association","keywords":"Sodium channel; Gating; Xenopus; Chemistry; Biophysics; Biochemistry; Sodium; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004976208,0.00004741366,0.00007052097,0.00007799896,0.0001869137,0.00001712715,0.0002073677,0.00007117236,0.000001938745],"category_scores_gemma":[0.0004436922,0.00003701707,0.00002318541,0.0001209917,0.0003943056,0.00003016873,0.00009109436,0.00005309299,7.223797e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006880143,"about_ca_system_score_gemma":0.00001113932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001319601,"about_ca_topic_score_gemma":7.781974e-8,"domain_scores_codex":[0.9993951,0.000003760267,0.0001651893,0.0001355721,0.0002281162,0.00007228417],"domain_scores_gemma":[0.9994753,0.00001173602,0.0003409513,0.000008736293,0.0001476679,0.00001562669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001402336,0.00001358406,0.01024872,0.00002386925,0.00000370614,1.711422e-9,0.00007094519,0.00003164626,0.9881812,0.001022908,0.0002778888,0.0001115577],"study_design_scores_gemma":[0.0001879563,0.00003730171,0.08700302,0.00006394528,0.000001861585,0.000003365725,0.0002909916,0.001158864,0.9091198,0.001860454,0.0002254348,0.00004693977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966421,0.00003014212,0.00001005927,0.001648097,0.00002397409,0.00008093743,0.0000123136,0.000001537087,0.001550881],"genre_scores_gemma":[0.9993901,0.00001445259,0.0002273733,0.00005203618,0.00005929364,0.000002930442,8.634415e-7,0.000002033954,0.0002509479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07906129,"threshold_uncertainty_score":0.1509513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03585460681770641,"score_gpt":0.2944640658364854,"score_spread":0.258609459018779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}