{"id":"W2588381983","doi":"10.1093/annonc/mdw383.38","title":"Evaluation of VeriStrat, a serum proteomic test, in the randomized, open-label, Phase 3 LUX-Lung 8 trial of afatinib versus erlotinib for the second-line treatment of advanced squamous cell carcinoma of the lung","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Regional Cancer Foundation; Ottawa Hospital","funders":"","keywords":"Medicine; Afatinib; Internal medicine; Erlotinib; Gastroenterology; Population; Lung cancer; Oncology; Epidermal growth factor receptor; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002493145,0.001828052,0.00245572,0.0004646529,0.000436572,0.001641013,0.001055907,0.002767221,0.003886543],"category_scores_gemma":[0.003046339,0.0006339662,0.002134492,0.0003951696,0.001118477,0.002230101,0.0004132237,0.004395019,0.001052593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001343349,"about_ca_system_score_gemma":0.001374835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007401726,"about_ca_topic_score_gemma":0.001821225,"domain_scores_codex":[0.998782,0.0006165784,0.00005066931,0.000250193,0.0001369489,0.0001635678],"domain_scores_gemma":[0.9984413,0.0005165649,0.0003644585,0.00009005637,0.0001208342,0.0004668506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9420513,0.005065765,0.005125105,0.000322335,0.001776356,0.00007396536,0.00006330147,0.001015892,0.004767449,0.0002357668,0.001656776,0.03784599],"study_design_scores_gemma":[0.786357,0.1884902,0.01425021,0.00006541497,0.001593609,0.0003833364,0.00009369377,0.003161009,0.002790866,0.000654502,0.002070671,0.00008948435],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883768,0.004858988,0.0007129116,0.001271146,0.0004801614,0.0007401377,0.001311345,0.0002102902,0.002038177],"genre_scores_gemma":[0.9922356,0.001283231,0.001138003,0.001143647,0.0002022072,0.000618717,0.001853605,0.00003204128,0.001492909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003886543,"threshold_uncertainty_score":0.01318514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1378102222120783,"score_gpt":0.4826661338630271,"score_spread":0.3448559116509488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}